Research of genetic markers in susceptibility to arterial hypertension in Russian Northwest region children

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Abstract

Вy PCR-RFLP procedures in groups of children of the Northwest region of Russia we investigated associations of some variants of CYP2J2, CYP4A11 and PTGIS genes participating in a metabolism of arachidonic acid and variants of CDH13, MTHFR, CDKN2BAS genes, and also an extra gene molecular marker rs11191548 T/C revealed on the basis of the GWAS method as candidates of risk of arterial hypertension, with development of a hypertension. The association of these markers with development of a hypertension in children didn't prove to be true.

About the authors

Mariya Dmitriyevna Kanayeva

Saint-Petersburg State University

Email: kanaeva.masha@yandex.ru
Student, Senior Researcher, Deptartament of Genetics and Selection

Andrey Sergeyevich Glotov

D. O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences

Email: anglotov@mail.ru
candidate of biological scientist, senior scientist, lab. of prenatal diagnosis of congenital and inherited diseases

Yelena Sergeyevna Vashukova

D. O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences

Email: vi_lena@list.ru
scientist, lab. of prenatal diagnosis of congenital and inherited diseases

Galina Igorevna Obraztsova

Federal heart, blood and endocrinology centre of ministry of health care

Email: galinaobraz@mail.ru
doctor of medical sciense

Vladislav Sergeyevich Baranov

D. O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences

Email: baranov@vb2475.spb.edu
professor, corresponding member of Russian Academy of of Medical Sciences, head of the laboratory of prenatal diagnosis of congenital and inherited diseases

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Copyright (c) 2013 Kanayeva M.D., Glotov A.S., Vashukova Y.S., Obraztsova G.I., Baranov V.S.

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