Diagnostic significance of biochemical and psychophysiological markers of depressive disorders in people’s army of Vietnam personnel

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Abstract

BACKGROUND: Currently, the diagnosis of depressive disorders is primarily based on clinical and psychopathological assessment of specific clinical symptoms. Although promising, molecular biological techniques are still not widely used in real-world practice. This necessitates developing and integrating techniques for qualitative assessment of biomarkers associated with depressive disorders. This will help to identify potential therapeutic targets. Furthermore, biomarkers can be used to assess the efficacy of drugs. The research into biomarkers of depressive disorders in People’s Army of Vietnam personnel is limited.

AIM: This study aimed to identify potential biomarkers of depressive disorders in People’s Army of Vietnam personnel using biochemical and psychophysiological techniques.

METHODS: Clinical, laboratory, and psychophysiological examinations were performed in military personnel with a confirmed depressive episode (ICD-10 code: F32) and healthy military personnel. The Hamilton Depression Rating Scale was used to assess the severity of depression. Neurotrophic factors were identified using commercial sandwich ELISA kits and calibration curves. Psychophysiological status was assessed by heart rate variability, visual motor response, reaction to a moving object, and dotting test scores (according to Ilyin).

RESULTS: Significant associations were found between depressive disorder and the assessed psychophysiological and biochemical markers.

CONCLUSION: Our findings support the use of biochemical and psychophysiological techniques in the diagnosis of depressive disorders in military personnel. Further research is warranted to assess the potential use and efficacy of these biomarkers for the prevention of mental disorders in psychophysiological support of People’s Army of Vietnam personnel.

About the authors

Huong Thi Bui

Joint Russian-Vietnamese Tropical Research and Technology Center

Email: vmedа_37@mil.ru
ORCID iD: 0009-0000-2827-2540

Cand. Sci. (Biology)

Viet Nam, Hanoi

Mo Thi Luong

Joint Russian-Vietnamese Tropical Research and Technology Center

Email: vmedа_37@mil.ru
ORCID iD: 0000-0002-6035-5933

Cand. Sci. (Chemistry)

Viet Nam, Hanoi

Nhai Thi Tran

Joint Russian-Vietnamese Tropical Research and Technology Center

Email: vmedа_37@mil.ru
ORCID iD: 0009-0009-4542-6375

employee of the Laboratory of Adaptation and Military Medicine

Viet Nam, Hanoi

Thuy Linh Thi Nguyen

Joint Russian-Vietnamese Tropical Research and Technology Center

Email: vmedа_37@mil.ru

laboratory assistant of the Laboratory of Adaptation and Military Medicine

Viet Nam, Hanoi

Bich Thi Pham

Institute of Natural Sciences — National Institute Hanoi

Email: vmedа_37@mil.ru
ORCID iD: 0009-0000-1473-7933

Cand. Sci. (Biology)

Viet Nam, Hanoi

Hai Yen Thi Ngo

Institute of Natural Sciences — National Institute Hanoi

Email: vmedа_37@mil.ru
ORCID iD: 0000-0002-6768-5062

Cand. Sci. (Biology)

Viet Nam, Hanoi

Thu Thi Vu

Institute of Natural Sciences — National Institute Hanoi

Email: vmedа_37@mil.ru
ORCID iD: 0000-0002-5971-2235

Cand. Sci. (Biology), Associate Professor

Viet Nam, Hanoi

Khanh Duc Tran

Institute of Natural Sciences — National Institute Hanoi

Email: vmedа_37@mil.ru
ORCID iD: 0009-0009-0595-6873
Viet Nam, Hanoi

Ca Van Nguyen

175 Military Clinical Hospital

Email: vmedа_37@mil.ru

psychiatrist

Viet Nam, Ho Сhi Minh City

Chan Van Dang

175 Military Clinical Hospital

Email: vmedа_37@mil.ru
ORCID iD: 0009-0001-2607-1072

Adjunct of the Psychiatry Department

Viet Nam, Ho Сhi Minh City

Tinh Xuan Do

103 Military Clinical Hospital

Email: vmedа_37@mil.ru

MD, Cand. Sci. (Medicine), the Head of the Psychiatry Department

Viet Nam, Hanoi

Tam Thi Nguyen

103 Military Clinical Hospital

Email: vmedа_37@mil.ru
ORCID iD: 0009-0003-3301-2585

MD, psychiatrist

Viet Nam, Hanoi

Cam Tu Thi Nguyen

Central Psychiatric Hospital No. 1

Email: vmedа_37@mil.ru

MD, psychiatrist

Viet Nam, Hanoi

Vladislav V. Yusupov

Military Medical Academy

Author for correspondence.
Email: vmedа_37@mil.ru
ORCID iD: 0000-0002-5236-8419
SPIN-code: 9042-3320

MD, Dr. Sci. (Medicine), Professor

Russian Federation, Saint Petersburg

Elena O. Filippova

Military Medical Academy

Email: vmedа_37@mil.ru
ORCID iD: 0009-0002-9529-5173
SPIN-code: 6495-2743
Russian Federation, Saint Petersburg

Svetlana N. Levich

Military Medical Academy

Email: vmedа_37@mil.ru
ORCID iD: 0000-0002-5874-1341
SPIN-code: 1278-3362
Russian Federation, Saint Petersburg

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