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Post a Comment Lipid-lowering and anti-atherosclerotic activity of the natural original enzyme preparation in the experiment
- Authors: Okunevich I.V.1, Klyueva N.N.1, Parfenova N.S.1, Belova E.V.1
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Affiliations:
- Institute of Experimental Medicine
- Issue: Vol 17, No 3 (2019)
- Pages: 79-84
- Section: Original study articles
- URL: https://ogarev-online.ru/RCF/article/view/16206
- DOI: https://doi.org/10.17816/RCF17379-84
- ID: 16206
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Abstract
The experimental large-scale investigation in vitro and in vivo is devoted to the results of a long-term study of the biological, lipid-lowering and anti-atherosclerotic activity of the original natural microbial enzyme preparation of cholesterol oxidase (CHO). In chronic experiments (rats, rabbits, dogs), low toxicity, good tolerability, and anti-atherosclerotic activity of the CHO preparation were established. To assess the effect of CHO in conditions of moderate nutritional dyslipoproteinemia, experiments were carried out in 3 species of animals (rats, guinea pigs, rabbits). It was shown the pronounced lipid-lowering effect of CHO in modeling dyslipoproteinemia.
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##article.viewOnOriginalSite##About the authors
Irina V. Okunevich
Institute of Experimental Medicine
Author for correspondence.
Email: irina_okunevich@mail.ru
Candidate of Biological Sciences, Senior Researcher, S.V. Anichkov Department of Neuropharmacology
Russian Federation, St. PetersburgNatalia N. Klyueva
Institute of Experimental Medicine
Email: nnklyueva@gmail.com
Candidate of Biological Sciences, Researcher of the Department of Biochemistry
Russian Federation, St. PetersburgNina S. Parfenova
Institute of Experimental Medicine
Email: nina.parf@mail.ru
Candidate of Medical Sciences, Senior Researcher of the Department of Biochemistry
Russian Federation, St. PetersburgElena V. Belova
Institute of Experimental Medicine
Email: irina_okunevich@mail.ru
Candidate of Biological Sciences, Researcher of the Department of Biochemistry
Russian Federation, St. PetersburgReferences
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