Nootropic effect of combined application of means from Baikal seal fat and cortexin at cerebral ischemia

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Abstract

In the present study, influence of the complex use of concentrate of polyunsaturated fatty acid (PUFA) from a fat of Baikal seal and cortexin on cognitive functions in rats with cerebral ischemia was evaluated. Cognitive impairments are early signs of cerebrovascular insufficiency, which are based on the development of pathobiochemical reactions that cause damage to the lipid and protein structures of cell membranes. It has been suggested that the administration of PUFA and cortexin will have a nootropic effect due to the synergy of their actions. The aim of the study was to determine the effect of PUFA and Cortexin on cognitive function in rats with cerebral ischemia. The study was performed on Wistar rats of both sexes. A model of cerebral ischemia was reproduced by occlusion of the left common carotid artery under ether anesthesia. Animals received PUFA (20 mg/kg) intragastrically once day for 14 days before surgery and for the next 10 days after in combination with administration of cortexin (4 mg/kg, i.p). For a comparative evaluation of the therapeutic efficacy of the complex use of PUFA and cortexin, three groups of animals were used: piracetam and monotherapy with PUFA, and Cortexin. Behavioral activity and cognitive functions in rats were determined using the methods: “open field”, “elevated plus maze”, “Morris water maze”. It has been established that combined use of PUFA and Cortexin stimulated locomotor and exploratory activity, reduced anxiety in animals and had a more effective nootropic effect as compared with monotherapy.

About the authors

Tatyana I. Sangadieva

D. Banzarov Buryat State University

Email: sagakc@mail.ru

Postgraduate, Department of Pharmacology and Traditional Medicine

Russian Federation, Ulan-Ude

Sergey M. Gulyaev

Institute of General and Experimental Biology, Siberian Branch of the Russian Academy of Sciences

Author for correspondence.
Email: s-gulyaev@inbox.ru
SPIN-code: 5084-6499

PhD, Senior Researcher of the Laboratory of Experimental Pharmacology

Russian Federation, Ulan-Ude

Galina P. Lamazhapova

D. Banzarov Buryat State University; East Siberian State University of Technology and Management

Email: lamazhap@mail.ru
SPIN-code: 1838-6392
Scopus Author ID: 6503925678

Doctor of Biological sciences, Department of Pharmacology and Traditional Medicine; Department of Biotechnology

Russian Federation, Ulan-Ude

References

  1. Вахнина Н.В. Сосудистые когнитивные нарушения // Неврология, нейропсихиатрия, психосоматика. – 2014. – № 1. – C. 74–79. [Vakhnina NV. Vascular cognitive impairments. Neurology, neuropsychiatry, psychosomatics. 2014;(1):74-79. (In Russ.)]
  2. Скворцова В.И., Нарциссов Я.Р., Бодыхов М.К., и др. Оксидантный стресс и кислородный статус при ишемическом инсульте // Журнал неврологии и психиатрии им. С.С. Корсакова. – 2007. – Т. 107. – № 1. – С. 30–36. [Skvortsova VI, Nartsissov YаR, Bodykhov MK, et al. Oxidative stress and oxygen status in ischemic stroke. Zh Nevrol Psikhiatr Im S.S. Korsakova. 2007;107(1):30-36. (In Russ.)]
  3. Singh RP, Sharad SS, Kapur S. Free Radicals and Oxidative Stress in Neurodegenerative Diseases: Relevance of Dietary Antioxidants. JIACM. 2004;5(3):218-225.
  4. Машковский М.Д. Лекарственные средства. – М.: Медицина, 1988. [Mashkovsky MD. Lekarstvennyye sredstva. Moscow: Meditsina; 1988. (In Russ.)]
  5. Bazinet RP, Laye S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci. 2014;15(12):771-785. https://doi.org/ 10.1038/nrn3820.
  6. Аверина Е.С. Исследование жирнокислотного состава жира байкальской нерпы Phoca (Pusa) Sibirica Gmel. и разработка новых путей его применения // Вестник Бурятского Университета. Химия. Физика. – 2009. – № 3. – С. 61–66. [Averina ES. Issledovanie zhirnokislotnogo sostava zhira baykal’skoy nerpy Phoca (Pusa) Sibirica Gmel. i razrabotka novykh putey ego primeneniya. Vestnik Buryatskogo Universiteta. Khimiya. Fizika. 2009;(3): 61-66. (In Russ.)]
  7. Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ / Под ред. Р.У. Хабриева. – М.: Медицина, 2005. [Rukovodstvo po eksperimental’nomu (doklinicheskomu) izucheniyu novykh farmakologicheskikh veshchestv. Ed. by R.U. Khabriyeva. Moscow: Meditsina; 2005. (In Russ.)]
  8. Hamazaki K, Kim HY. Differential modification of the phospholipid profile by transient ischemia in rat hippocampal CA1 and CA3 regions. Prostaglandins Leukot Essent Fatty Acids. 2013;88(4):299-306. https://doi.org/ 10.1016/j.plefa.2013.01.003.
  9. Смолко Д.Г. Динамика когнитивных функций и биомаркеров ишемии мозга при лечении кортексином пациентов с хронической сосудисто-мозговой патологией // Международный неврологический журнал. – 2017. – № 1. – С. 128–133. [Smolko DH. The dynamics of cognitive functions and biomarkers of cerebral ischemia duringthe cortexin treatment of patients with chronic cerebrovascular pathology. International neurological journal. 2017;(1):128-132. (In Russ.)] https://doi.org/ 10.22141/2224-0713.1.87.2017.96548.
  10. Serhan CN. Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins. Curr Opin Clin Nutr Metab Care. 2005;8(2):115-121. https://doi.org/ 10.1097/00075197-200503000-00003.
  11. Bazan NG. Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. Curr Opin Clin Nutr Metab Care. 2007;10(2):136-141. https://doi.org/ 10.1097/MCO.0b013e32802b7030.

Copyright (c) 2020 Sangadieva T.I., Gulyaev S.M., Lamazhapova G.P.

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