Experimental assessment of the KK1 peptide effectiveness for prevention of the CNS delayed impairments after acute intoxication with carbon monoxide

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Abstract

Intoxication with the carbon monoxide leads to the development the early and delayed neuropsychological impairments. Oxygen therapy is used usually as an antidote for the treatment of acute carbon monoxide poisoning. The synthetic analogues of endogenous peptides were shown to prevent the neuropsychological impairments. One of them is KK1, a tetrapeptide acetyl-(D-Lys)-Lys-Arg-Arg-amide, assessed as a structural analogue of corticotropine. The efficiency of the synthetic tetrapeptide KK1 for the prevention of the CNS delayed impairments after acute carbon monoxide poisoning has been evaluated in this study.

About the authors

Pavel Gennadievich Tolkach

S. M. Kirov Military Medical Academy

Email: basharin1@mail.ru
Post Graduate Student, Dept. of Military Toxicology and Medical Defense

Vadim Alexandrovich Basharin

S. M. Kirov Military Medical Academy

Email: basharin1@mail.ru
Dr. Sci. (Toxicology), Chief, Dept. of Military Toxicology and Medical Defense

Alexandre Nikolayevich Grebenyuk

S. M. Kirov Military Medical Academy

Dr. Sci. (Toxicology), Professor, Dept. of Military Toxicology and Medical Defense

Alexandre Alexandrovich Kolobov

State Research Institute of Superpure Biopreparations

Dr. Sci. (Biology), Chief of the Laboratory

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Copyright (c) 2015 Tolkach P.G., Basharin V.A., Grebenyuk A.N., Kolobov A.A.

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