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Post a Comment State of lipid metabolism in patients receiving androgen replacement therapy
- Authors: Popov P.S.1,2, Kournikova I.A.1, Torshin V.I.1, Malyutina N.N.2
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Affiliations:
- RUDN University
- E.A. Vagner Perm State Medical University
- Issue: Vol 37, No 5 (2020)
- Pages: 20-26
- Section: Original studies
- URL: https://ogarev-online.ru/PMJ/article/view/57668
- DOI: https://doi.org/10.17816/pmj37520-26
- ID: 57668
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Abstract
Objective. To assess the state of lipid metabolism indicators and predict cardiovascular risk in patients with secondary (acquired) hypogonadism on the background of androgen replacement therapy. Testosterone replacement therapy is often used in modern medicine for diagnosed androgen deficiency in patients of any age group. There are quite a lot of publications devoted to diagnosis and treatment, but the effectiveness and safety of any therapy is determined by several factors, of which two were considered in the presented study – dose-dependent effect and compliance.
Material and methods. Sixty two patients aged 30 to 52 years with androgen deficiency and a low risk of developing cardiovascular diseases were examined according to the Princeton Consensus criteria. Patients were divided into groups depending on the severity of androgen deficiency and the duration of therapy. Complaints, objective status, muscle strength, daily blood pressure and heart rate monitoring data, lipidogram and sex hormone indicators were evaluated.
Results. The obtained data suggest that androgen replacement therapy in doses that lead to an increase in the level of testosterone in the blood above the upper limit of reference values had a negative impact on the lipid spectrum and increased cardiovascular risk for this group of patients.
Conclusions. The analyzed approach to therapy of androgen deficiency should provide an individual adjustment of dosage on the background of determining the target blood testosterone level.
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##article.viewOnOriginalSite##About the authors
P. S. Popov
RUDN University; E.A. Vagner Perm State Medical University
Email: dr-malyutina@yandex.ru
Lecturer, Department of Hospital Therapy with Course of Endocrinology, Hematology and Clinical Laboratory Diagnostics
Russian Federation, Moscow; PermI. A. Kournikova
RUDN University
Email: dr-malyutina@yandex.ru
MD, PhD, Professor, Department of Hospital Therapy with Course of Endocrinology, Hematology and Clinical Laboratory Diagnostics
Russian Federation, MoscowV. I. Torshin
RUDN University
Email: dr-malyutina@yandex.ru
MD, PhD, Professor, Head of Department of Normal Physiology
Russian Federation, MoscowN. N. Malyutina
E.A. Vagner Perm State Medical University
Author for correspondence.
Email: dr-malyutina@yandex.ru
MD, PhD, Professor, Head of Department of Faculty Therapy №2, Professional Pathology, Clinical Laboratory Diagnostics
Russian Federation, PermReferences
- Vertkin A.L., Аrinina E.N., Morgunov L.Yu. etc. The prevalence of age-related hypogonadism in men with with somatic pathology. Human Health as the basis of national security: materials of the Siberian Congress. Krasnoyarsk 2006: 298–299 (in Russian).
- Lunenfeld B., Mskhalaya G., Zitzmann M., Arver S., Kalinchenko S., Tishova Y. et al. Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men. Aging Male 2015; 18 (1): 5–15. doi: 10.3109/13685538.2015.1004049
- Pashkova E.Yu., Rozhdestvenskaya O.A. Age-related androgen deficiency in men: etiology, clinic, diagnosis, treatment. Andrology and genital surgery 2015; 1: 95–101. DOI: 10.17650/ 2070-9781-2015-1-95-101 (in Russian).
- Grossman H., Fabre B., Lopez M. et al. Complex relationship between sex hormones, insulin resistance and leptin in men with and without prostatic disease. Aging Male 2015; 19 (1): 40–45. doi: 10.3109/13685538. 2015.1100600. PMID: 26526283
- Ametov A. S., Pashkova E. Yu. Evolution of testosterone replacement therapy. New forms – new features. Endocrinology. News. Opinions. Training 2017; 2: 55–65. doi: 10.24411/2304-9529-2017-00006 (in Russian).
- Soisson V., Brailly T.S., Empana J.P., Feart C., Ryan J. et al. Low plasma testosterone and elevated carotid intima-media thickness: importance of low-grade inflammation in elderly men. Atherosclerosis 2012; 223: 244–249.
- Muller M., Van Der Schouw Y.T., Thijssen J.H., Grobbee D.E. Endogenous sex hormones and cardiovascular disease in men. J Clin Endocrinol Metab 2003; 88: 5076–5086.
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