GENDER PECULIARITIES OF LEPTIN, SOLUBLE LEPTIN RECEPTORS AND RESISTIN LEVELS IN PATIENTS SUFFERING FROM ARTERIAL HYPERTENSION ASSOCIATED WITH OBESITY

Aim. At present, the problem of obesity as a risk factor for cardiovascular diseases remains actual. The aim of the work was to assess the gender peculiarities of the levels of adipokin and soluble leptin receptors in patients suffering from arterial hypertension (AH) associated with obesity. Materials and methods. The study enclosed 70 patients with AH. The parameters: mean body mass index (BMI) - 38,0 ± 9 kg/m2, mean age - 48,2 ± 2,4 years. There were 40 patients with obesity without AH and metabolic disorders and 30 practically healthy persons comparable by sex and age. Results. Leptin and resistin levels were reliably higher, but soluble leptin receptor concentration was lower in the group of AH patients with obesity. In the group of women, higher concentrations of leptin and resistin, and lower concentrations of soluble leptin receptors were observed than in the group of men. Correlation analysis indicated direct correlation of leptin and resistin with BMI, HOMA and TH indices, DAP level and reverse correlation of soluble leptin receptors with HOMA index. Conclusions. Thus, hormonal status of adipose tissue in women suffering from AH associated with obesity is characterized by higher leptin and resistin levels than in men. The cause of leptin resistance can be a low level of soluble leptin receptors.

Arterial hypertension, obesity, leptin, resistin, soluble leptin receptors