The concentration of serum neopterin in patients with surgical treatment of spondyloarthrosis complicated byfacet syndrome
- Authors: Pronin A.Y.1,2, Karakulova Y.V.1,2, Sosnin D.Y.1
-
Affiliations:
- E.A. Vagner Perm State Medical University
- City Clinical Hospital № 4
- Issue: Vol 41, No 1 (2024)
- Pages: 5-12
- Section: Original studies
- URL: https://ogarev-online.ru/PMJ/article/view/254839
- DOI: https://doi.org/10.17816/pmj4115-12
- ID: 254839
Cite item
Abstract
Objective. To study the concentration of serum neopterin in patients before and after surgical treatment of pain syndrome caused by the formation of facet syndrome associated with spondyloarthrosis.
Materials and methods. The study involved 52 patients (32 men and 20 women) hospitalized to the neurosurgical department of the City Clinical Hospital No. 4. The main group consisted of 26 patients with spondyloarthrosis complicated by chronic pain associated with facet syndrome. The comparison group (n=26) consisted of patients with pain syndrome in radiculopathy. The control group (comparable in gender and age) consisted of 10 people who underwent periodic examination. The concentration of neopterin in blood serum was determined by solid-phase enzyme immunoassay (ELISA) using the Neopterin ELISA kit (cat. No. 59321; lot ENO230) ("IBL", Germany).
Results. Statistically significant differences in the level of serum neopterin concentration (p = 0.0016) were revealed between the studied groups. The highest concentration of neopterin was noted in the comparison group, where it was 10.31 ± 2.02 nmol/l, exceeding the results of the control group (p=0.02256) and the main group (p=0.04996). Three months after surgical treatment of patients in the main group, the median content of serum neopterin decreased by 1.161 times (p = 0.049029).
Conclusion. Further studies to clarify the influence of pain on metabolic processes and neopterin in particular are required.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Artur Yu. Pronin
E.A. Vagner Perm State Medical University; City Clinical Hospital № 4
Email: proninartur@icloud.com
ORCID iD: 0009-0003-9555-8014
Candidate for a Degree of the Department of Neurology and Medical Genetics, Neurosurgeon
Russian Federation, Perm; PermYuliya V. Karakulova
E.A. Vagner Perm State Medical University; City Clinical Hospital № 4
Email: julia.karakulova@mail.ru
ORCID iD: 0000-0002-7536-2060
SPIN-code: 5066-6556
MD, PhD, Professor, Head of the Department of Neurology and Medical Genetics
Russian Federation, Perm; PermDmitriy Yu. Sosnin
E.A. Vagner Perm State Medical University
Author for correspondence.
Email: sosnin_dm@mail.ru
ORCID iD: 0000-0002-1232-8826
SPIN-code: 4204-6796
MD, PhD, Professor of the Department of Faculty Therapy №2, Occupational Pathology and Clinical Laboratory Diagnostics
Russian Federation, PermReferences
- Колотов Е.Б., Луцик А.А. Сочетание дискогенных болей и рефлекторных синдромов спондилоартроза (диагностика и лечение). Неврологический журнал 2009; 14 (3): 26–28. / Kolotov E.B., Lutsik A.A. Combination of discogenic pains and reflex syndromes of spondyloarthrosis (diagnosis and treatment). Neurological Journal 2009; 14: 3: 26–28 (in Russian).
- Reed M.L., Golish S.R., Schofferman J. Interdisciplinary care for lumbar Spine disorders. Orthopaedic Knowledge Update: Spine 2018; 5: 127–150.
- Садоха К.А., Головко А.М. Пояснично-крестцовая компрессионная радикулопатия. Медицинские новости 2020; 1 (304): 9–15. / Sadoha K.A., Golovko A.M. Lumbar-sacral compression radiculopathy. Medicinskie novosti 2020; 1 (304): 9–15 (in Russian).
- Ra I.H., Min W.K. Traumatic bilateral facet dislocation of lumbar spine: "double facet sign". Spine J. 2013; 13 (11): 1705–1707. doi: 10.1016/j.spinee.2013.07.477
- Ridley W.E., Xiang H., Han J., Ridley L.J. Shark's fin sign: Unilateral facet joint dislocation. J Med Imaging Radiat Oncol. 2018; 62: l: 1: 156. doi: 10.1111/1754-9485.29_12786
- Laborie F., Béal C., Sigaux J. Lumbar facet joint effusion. Joint Bone Spine. 2023; 90 (3): 105516. doi: 10.1016/j.jbspin.2022.105516
- Alexander G.M., Reichenberger E., Peterlin B.L., Perreault M.J., Grothusen J.R., Schwartzman R.J. Plasma amino acids changes in complex regional pain syndrome. Pain Res Treat. 2013; 2013: 742407. doi: 10.1155/2013/742407
- Hamerlinck F.F. Neopterin: a review. Exp Dermatol. 1999; 8 (3): 167–176. doi: 10.1111/j.1600-0625.1999.tb00367.x
- Свиридов Е.А., Телегина Т.А. Неоптерин и его восстановленные формы: биологическая роль и участие в клеточном иммунитете. Успехи биологической химии 2005; 45: 355–390. / Sviridov E.A., Telegina T.A. Neopterin and its restored forms: biological role and participation in cellular immunity. Advances in biological chemistry 2005; 45: 355–390 (in Russian).
- Murr C., Widner B., Wirleitner B., Fuchs D. Neopterin as a Marker for Immune System Activation. Current Drug Metabolism 2002; 3: 175–187. doi: 10.2174/1389200024605082
- Каракулова Ю.В., Сексяев Н.Е., Соснин Д.Ю. Концентрация неоптерина в ликворе у ВИЧ-инфицированных пациентов с поражением центральной нервной системы. Лабораторная служба 2021; 10 (3): 21–27. doi: 10.17116/labs20211003121 / Karakulova Yu.V., Seksyaev N.E., Sosnin D.Yu. The concentration of neopterin in the cerebrospinal fluid in HIV-infected patients with central nervous system damage. Laboratory service 2021; 10 (3): 21–27. doi: 10.17116/labs20211003121 (in Russian)
- Berdowska A., Zwirska-Korczala K. Neopterin measurement in clinical diagnosis. J Clin Pharm Ther. 2001; 26 (5): 319–329. DOI: 10.10 46/j.1365-2710.2001.00358.x
- Huang K., Du G., Wei C., Gu S., Tang J. Elevated serum lactoferrin and neopterin are associated with postoperative infectious com-plications in patients with acute traumatic spinal cord injury. Arch Med Sci. 2013; 9 (5): 865–871. doi: 10.5114/aoms.2013.38680
- Пронин А.Ю., Каракулова Ю.В. Динамика показателей неоптерина и NSE в сыворотке крови пациентов с болевым синдромом при спондилоартрозе поясничного отдела позвоночника до и после проведения высокочастотной денервации фасеточных суставов. Неврологические чтения в Перми: материалы межрегиональной научно-практической конференции с международным участием, посвященной 100-летию кафедры неврологии и медицинской генетики им. В.П. Первушина, Пермь, 21–23 октября 2021 года. Пермь: Пермский национальный исследовательский политехнический университет 2021; 148–150. / Pronin A.Yu., Karakulova Yu.V. Dynamics of indicators of neopterin and NSE in the blood serum of patients with pain syndrome with lumbar spine spondyloarthrosis before and after high-frequency denervation of facet joints. Neurological readings in Perm: Materials of the interregional scientific and practical conference with international participation dedicated to the 100th anniversary of the Department of Neurology and Medical Genetics named after V.P. Pervushin, Perm, October 21–23, 2021. Perm: Perm National Research Polytechnic University 2021; 148–150 (in Russian).
- Mishra A., Agrawal D., Singh P.K. Delayed presentation of post-traumatic bilateral cervical facet dislocation: a series of 4 cases. Neurol India. 2014; 62 (5): 540–2. doi: 10.4103/0028-3886.144454
- Jain M., Khuntia S., Rao B.P. Neglected Bilateral Facet Dislocation of the Cervical Spine with Intact Neurology: Reduction Technique. Asian J Neurosurg. 2020; 15 (3): 773–776. doi: 10.4103/ajns.AJNS_27_20
- Погорелова Е.И., Буданова М.В., Панина О.А. Неоптерин как прогностический фактор течения острых респираторных инфекций. Современные достижения химико-биологических наук в профилактической и клинической медицине: сборник научных трудов всероссийской научно-практической конференции с международным участием, Санкт-Петербург, 3 декабря 2020 года. Под ред. А.В. Силина, Л.Б. Гайковой. Ч. 1. Санкт-Петербург: Северо-Западный государственный медицинский университет имени И.И. Мечникова 2020; 310–314. / Pogorelova E.I., Budanova M.V., Panina O.A. Neopterin as a prognostic factor of the course of acute respiratory infections. Modern achievements of chemical and biological sciences in preventive and clinical medicine: Collection of scientific papers of the All-Russian Scientific and Practical Conference with international participation, St. Petersburg, December 03, 2020. Edited by A.V. Silin, L.B. Gaikova. Part 1. St. Petersburg: I.I. Mechnikov Northwestern State Medical University 2020; 310–314 (in Russian).
- Gieseg S.P., Baxter-Parker G., Lindsay A. Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing? Antioxidants (Basel) 2018; 7 (7): 80. doi: 10.3390/antiox7070080
- Avanzas P., Arroyo-Espliguero R., Cosin-Sales J., Quiles J., Zouridakis E., Kaski J.C. Prognostic value of neopterin levels in treated patients with hypertension and chest pain but without obstructive coronary artery disease. Am J Cardiol. 2004; 1; 93 (5): 627–9. doi: 10.1016/j.amjcard.2003.11.035
- Euteneuer F., Schwarz M.J., Hennings A., Riemer S., Stapf T., Selberdinger V., Rief W. Psychobiological aspects of somatization syndromes: contributions of inflammatory cytokines and neopterin. Psychiatry Res. 2012; 30 (195): 1–2: 60–65. doi: 10.1016/j.psychres.2011.07.032
Supplementary files
