Email this article COMPARATIVE STUDY OF HUMAN STEROID-PRODUCING SUB-CELLULAR FRACTIONS IMMUNE REACTIVITY IN AUTOIMMUNE FAILURE
- Authors: Khokhlov PP1, Sapronov NS1, Shabanov PD1
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Affiliations:
- Institute of Experimental Medicine NWB RAMS
- Issue: Vol 12, No 1 (2012)
- Pages: 59-65
- Section: Articles
- URL: https://ogarev-online.ru/MAJ/article/view/9878
- DOI: https://doi.org/10.17816/MAJ12159-65
- ID: 9878
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Abstract
The purpose of the study was to identify and determine the immune reactivity of sub-cellular fractions of sreroidogenic cells and to measure quantitatively the organ specific autoantibodies. The high immunogenicity of microsomal fractions of human adrenal and gonad steroid-producing cells was shown as a result of investigation. The border levels for natural organ specific autoantibodies out of pathologies were established. In laboratory materials, the statistically significant increase of plasma antibodies to adrenocortical, ovarian and testicular antigens in immune mediated destruction of adrenals and gonads in humans was shown. The results are in good accordance with data of high immune reactivity of steroid genesis hydrolase enzymes. Their pathogenic role is more significant than the same of steroid hormones in states of immune pathology of the adrenal glands and gonads.
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##article.viewOnOriginalSite##About the authors
P P Khokhlov
Institute of Experimental Medicine NWB RAMSSt.-Petersburg, Russia
N S Sapronov
Institute of Experimental Medicine NWB RAMS
Email: sns@iemrams.spb.ru
St.-Petersburg, Russia
P D Shabanov
Institute of Experimental Medicine NWB RAMSSt.-Petersburg, Russia
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