Open Access
Access granted
Subscription Access
Vol 12, No 3 (2012)
- Year: 2012
- Articles: 38
- URL: https://ogarev-online.ru/MAJ/issue/view/591
Articles
BISPECIFIC PROTEIN KINASE PHOSPHATASE DUSP9 AS A NEW BIOMARKER FOR CLEAR CELL RENAL CELL CARCINOMA AND PROSPECTS FOR ITS UTILISING FOR GENE THERAPY
Abstract
The most common histological type of RCC is clear cell carcinoma. Although in 70% of the cases renal cancer is diagnosed at the localized stage, metastases develop in more than a half of the patients after surgical treatment. Resistance of RCC against chemotherapy and radiotherapy is the reason of high mortality rate of patients with metastatic renal cancer. Understanding of molecular mechanisms of tumor formation and growth would allow for the development of new diagnostic and prognostic markers, and new treatment strategies of malignant tumors. In this article we discuss the novel trends in the field of treatment of kidney malignant diseases. In particular, we address the questions of prospects and problems of gene therapy approaches for the treatment of kidney cancer. During the recent years we have investigated the DUSP9 gene. This paper summarizes our own data and the results of other investigations of the properties and functions of DUSP9 gene. We conclude that DUSP9 can be considered as a new biomarker for clear cell carcinoma, as well as the gene for kidney cancer gene therapy.
Medical academic journal. 2012;12(3):7-14
7-14
ADVANCED MORPHOLOGICAL APPROACHES TO THE STUDY OF PERIPHERAL NERVE REGENERATION
Abstract
This review is devoted to the recovery of peripheral nerves after injury. The prevalence of injuries of nerves and lack of knowledge about the mechanisms of regeneration of peripheral nerve fibers determine the actuality of the problem. Characteristics of the main methods for selective immunohistochemical detection of neuronal markers, proteins of axonal transport, markers of Schwann cells and myelin sheaths are given in the review. Methods of retrograde labeling of motoneurons and sensory neurons are also characterized. The most interesting results of recent experimental studies using these methods are given in the review. There are two basic strategies to connect the segments of nerve damage: the use of biodegradable scaffolds and conduits and the application of stem cells. Stem cells are source of the growth and trophic factors. This paper contains the necessary information about the complicated and efficient methods of molecular and cellular analysis used in studying of the mechanisms of recovery processes which develop in the nervous system after injury. The widespread use of these morphological approaches should help improve the efficiency of scientific research on the development of new medical technologies.
Medical academic journal. 2012;12(3):15-29
15-29
ACTIVATION OF CEREBROVASCULAR PATIENTS’ SUPPRESSOR CELLS
Abstract
The work presentsthe study of materials especially the immune system changes, including Treg lymphocytes in patients with acute and chronic cerebral ischemia. Changes in the immune status of the patients seen in reducing the total number of T-lymphocytes. It is shown that in patients with cerebrovascular diseases, changes in the functional state of cells and, in particular, in the system of Treg cells responsible for immune suppression.
Medical academic journal. 2012;12(3):30-34
30-34
OBShchIE I SPETsIFIChESKIE MEKhANIZMY PATOGENEZA TREVOZhNYKh I DEPRESSIVNYKh RASSTROYSTV V MODELYaKh NA ZhIVOTNYKh: ROL' TRANSKRIPTsIONNYKh FAKTOROV
Medical academic journal. 2012;12(3):35-37
35-37
MORFOFUNKTsIONAL'NYE OSNOVY OTKLONENII V POVEDENII NA MODELI OSTROGO VITAL'NOGO STRESSA U KRYS
Medical academic journal. 2012;12(3):37-40
37-40
BIOMARKERY DESTRUKTIVNYKh PROTsESSOV U BOL'NYKh ShIZOFRENIEY S TARDIVNOY DISKINEZIEY NA FONE DLITEL'NOY ANTIPSIKhOTIChESKOY TERAPII
Medical academic journal. 2012;12(3):40-42
40-42
ROL' GENA SWS V FORMIROVANII NEIROMYShEChNYKh SOEDINENIY DROSOPHILA MELANOGASTER I VYPOLNENII SINAPTIChESKIKh FUNKTsIY
Medical academic journal. 2012;12(3):42-43
42-43
PATOMORFOLOGIChESKIE ASPEKTY LOKAL'NOGO PRIMENENIYa EPIDERMAL'NOGO FAKTORA ROSTA PRI TERMIChESKOY TRAVME
Medical academic journal. 2012;12(3):43-45
43-45
NEYROGORMONAL'NYE aspekty formirovaniya POSTSTRESSORNOGO RASSTROYSTVA U PRENATAL'NO STRESSIROVANNYKh SAMTsOV KRYS
Medical academic journal. 2012;12(3):46-48
46-48
DINAMIKA POKAZATELEY ENDOTOKSEMII PRI OSTROM OTRAVLENII AMITRIPTILINOM
Medical academic journal. 2012;12(3):48-50
48-50
VLIYaNIE EKSPERIMENTAL'NOY OSTROY KRATKOVREMENNOY VYRAZhENNOY NORMOBARIChESKOY GIPOKSII NA POKAZATELI SVOBODNYKh AMINOKISLOT PLAZMY KROVI ChELOVEKA
Medical academic journal. 2012;12(3):50-53
50-53
OSOBENNOSTI EKSPRESSII MINERALOKORTIKOIDNYKh RETsEPTOROV V NEOKORTEKSE KRYS PRI PRED\"YaVLENII RAZLIChNYKh REZhIMOV GIPOBARIChESKOY GIPOKSII
Medical academic journal. 2012;12(3):53-55
53-55
SOChETANNOE PRIMENENIE IN VITRO FAKTORA NEKROZA OPUKhOLI-α (AL'NORIN) S PROTIVOOPUKhOLEVYMI PREPARATAMI NA KLETOChNYKh LINIYaKh MELANOM
Medical academic journal. 2012;12(3):55-57
55-57
VLIYaNIE SODERZhANIYa O 2 V SREDE NA MUL'TIPOTENTNYE MEZENKhIMAL'NYE KLETKI-PREDShESTVENNIKI KOSTNOGO MOZGA RAZNOVOZRASTNYKh KRYS
Medical academic journal. 2012;12(3):57-59
57-59
PROTIVOOPUKhOLEVAYa AKTIVNOST' I MOLEKULYaRNYY MEKhANIZM DEYSTVIYa FUKOIDANOV BURYKh VODOROSLEY
Medical academic journal. 2012;12(3):59-60
59-60
PROTIVOVOSPALITEL'NAYa AKTIVNOST' KhITOZANA I EGO NIZKOMOLEKULYaRNOGO PROIZVODNOGO
Medical academic journal. 2012;12(3):60-61
60-61
SRAVNITEL'NYY ANALIZ SVOYSTV POSTOYaNNYKh LINIY EMBRIONAL'NYKh STVOLOVYKh KLETOK ChELOVEKA, PRI KUL'TIVIROVANII V RAZNYKh SISTEMAKh
Medical academic journal. 2012;12(3):61-63
61-63
KhARAKTERISTIKA RADIATsIONNO-INDUTsIROVANNYKh IZMENENIY SUBPOPULYaTsIONNOGO SOSTAVA KUL'TURY KLETOK LINII HeLa
Medical academic journal. 2012;12(3):63-65
63-65
IZMENENIE ChUVSTVITEL'NOSTI BAKTERIY ESCHERICHIA COLI K DEYSTVIYu ANTIBIOTIKOV V PRISUTSTVII RASTITEL'NYKh POLIFENOLOV
Medical academic journal. 2012;12(3):65-66
65-66
IZMENENIE PROLIFERATsII, MIGRATsII, OBRAZOVANIYa TRUBOK SOSUDOV I SEKRETsII TsITOKINOV ENDOTELIAL'NYMI KLETKAMI LINII EA.Nu926 V PRISUTSTVII FAKTOROV, SEKRETIRUEMYKh TKAN'Yu PLATsENTY
Medical academic journal. 2012;12(3):67-69
67-69
VZAIMOSVYaZI MEZhDU AKTIVNOST'Yu MONOAMINOOKSIDAZ I SVOBODNORADIKAL'NYM OKISLENIEM V MITOKhONDRIYaKh GOLOVNOGO MOZGA PRI STRESSE
Medical academic journal. 2012;12(3):70-72
70-72
REGULYaTsIYa TsERULOPLAZMINOM ANTIGIPOKSIChESKOY AKTIVNOSTI APO-LAKTOFERRINA NA MODELI KRYS, POLUChAVShIKh DIETU S KhLORIDOM SEREBRA
Medical academic journal. 2012;12(3):72-73
72-73
NATRIY-YODIDNYY SIMPORTER KAK REPORTERNYY BELOK V RAZRABOTKE GENOTERAPEVTIChESKIKh PREPARATOV
Medical academic journal. 2012;12(3):74-75
74-75
ROL' BELKA STAT5 V EKSPRESSII RETsEPTORA INTERLEYKINA-2 V LIMFOTsITAKh KROVI ChELOVEKA
Medical academic journal. 2012;12(3):75-77
75-77
IDENTIFIKATsIYa ADDUKTOV FOSFORORGANIChESKIKh OTRAVLYaYuShchIKh VEShchESTV S BELKAMI KROVI METODAMI FOSFOPROTEOMIKI
Medical academic journal. 2012;12(3):77-79
77-79
VOZMOZhNOSTI REGULYaTsII PROATEROGENNYKh SVOYSTV MIELOPEROKSIDAZY S POMOShch'Yu VEShchESTV, INGIBIRUYuShchIKh EE AKTIVNOST' I PREPYaTSTVUYuShchIKh EE VZAIMODEYSTVIYu S LIPOPROTEINAMI NIZKOY PLOTNOSTI
Medical academic journal. 2012;12(3):80-81
80-81
ISSLEDOVANIE PEPTIDNYKh NOSITELEY DLYa ADRESNOY DOSTAVKI INTERFERIRUYuShchIKh RNK S TsEL'Yu PODAVLENIYa EKSPRESSII GENA VEGFA PRI ENDOMETRIOZE
Medical academic journal. 2012;12(3):81-82
81-82
OTsENKA IMMUNNOGO STATUSA U BOL'NYKh SOSUDISTYMI ZABOLEVANIYaMI GOLOVNOGO MOZGA
Medical academic journal. 2012;12(3):83-85
83-85
REKOMBINANTNYE POLIPEPTIDY KAK BIOMARKERY OTsENKI IMMUNOLOGIChESKOI EFFEKTIVNOSTI VAKTsINATsII ZhIVOY ChUMNOY VAKTsINOY U LYuDEY
Medical academic journal. 2012;12(3):85-87
85-87
OSOBENNOSTI POVERKhNOSTNOY EKSPRESSII AKTIVIRUYuShchIKh RETsEPTOROV VROZhDENNOGO IMMUNITETA NA SUBPOPULYaTsIYaKh MONOTsITOV
Medical academic journal. 2012;12(3):87-89
87-89
FORMIROVANIE NEITROFIL'NYKh VNEKLETOChNYKh LOVUShEK V USLOVIYaKh GIPOKINETIChESKOGO STRESSA
Medical academic journal. 2012;12(3):90-91
90-91
VLIYaNIE TsITOKINOV NA MIGRATsIONNUYu AKTIVNOST' KLETOK TROFOBLASTA LINII Jeg-3
Medical academic journal. 2012;12(3):92-93
92-93
MORFOLOGIChESKIM ANALIZ I DINAMIKA GIDROKORTIZON-INDUTsIROVANNOY ATROFII TIMUSA
Medical academic journal. 2012;12(3):94-96
94-96
VLIYaNIE ANTIMIKROBNOGO PEPTIDA INDOLITsIDIN NA FUNKTsIONAL'NUYu AKTIVNOST' MAKROFAGOV PRI TERMIChESKIKh OZhOGAKh KOZhI
Medical academic journal. 2012;12(3):96-98
96-98
STIMULYaTsIYa TsITOTOKSIChESKOGO OTVETA V KUL'TURE MONONUKLEARNYKh KLETOK BOL'NYKh RAKOM MOLOChNOY ZhELEZY S POMOShch'Yu DENDRITNYKh KLETOK, TRANSFETsIROVANNYKh POLIEPITOPNOY DNK-KONSTRUKTsIEY
Medical academic journal. 2012;12(3):98-99
98-99
REKOMBINANTNYY BELOK TEPLOVOGO ShOKA Hsp70 V IMMUNOTERAPII OPUKhOLEY GOLOVNOGO MOZGA
Medical academic journal. 2012;12(3):99-101
99-101
SERGEY FEDOROVICh BAGNENKO K 55-LETIYu SO DNYa ROZhDENIYa
Medical academic journal. 2012;12(3):102-103
102-103
PRAVILA OFORMLENIYa STATEY
Medical academic journal. 2012;12(3):104-104
104-104