Email this article CORRECTION OF STRESS-INDUCED HORMONAL CHANGES BY THE RIL-2 MEDICATION IN EXPERIMENTAL TRAUMATIC BRAIN INJURY
- Authors: Fomicheva EE1, Shanin SN1, Filatenkova TA1, Serebryanaya NB1,2,3
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Affiliations:
- Institute of Experimental Medicine, Saint Petersburg
- Saint Petersburg State University, Saint Petersburg
- North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg
- Issue: Vol 19, No 1S (2019)
- Pages: 199-200
- Section: Articles
- URL: https://ogarev-online.ru/MAJ/article/view/19396
- ID: 19396
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Abstract
Traumatic brain injury (TBI) leads to steady stress reaction that may substantially influence on posttraumatic period. Stress changes concentration of sex hormones too, that play role of neurosteroids in CNS. The aim of the study was to detect changes in corticosterone and testosterone concentration in serum of experimental animals during recovery period after TBI. And also to find possibility of disturbance correction by cytokine preparation rIL-2 (ronkoleukin). After TBI both experimental and control group of animals get daily injections of recombinant human interleukin-2. TBI decreased the level of corticosterone on 30%, the injection of rIL-2 increased it. Testosterone slightly changed after TBI. But it’s level increased when after TBI the injections of rIL-2 were done. The obtained results can be considered as evidence of the stress reaction normalization in animals after TBI and under the conditions of their treatment with rIL-2.
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##article.viewOnOriginalSite##About the authors
E E Fomicheva
Institute of Experimental Medicine, Saint Petersburg
S N Shanin
Institute of Experimental Medicine, Saint Petersburg
T A Filatenkova
Institute of Experimental Medicine, Saint Petersburg
N B Serebryanaya
Institute of Experimental Medicine, Saint Petersburg; Saint Petersburg State University, Saint Petersburg; North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg
References
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