Email this article COMBINED ACTION OF ANTIMICROBIAL PEPTIDES AND NONIONIC SURFACTANTS TOWARDS BACTERIA
- Authors: Zharkova MS1, Orlov DS1, Kolobov AA2, Shamova OV1
-
Affiliations:
- Institute of Experimental Medicine, Saint Petersburg
- State Research Institute of Highly Pure Biopreparations, Saint Petersburg
- Issue: Vol 19, No 1S (2019)
- Pages: 194-196
- Section: Articles
- URL: https://ogarev-online.ru/MAJ/article/view/19394
- ID: 19394
Cite item
Abstract
Antimicrobial peptides (AMPs) have certain resemblance with surfactants. Using checkerboard titrations and spectrophotometrical analysis of the membrane permeability for chromogenic markers, we found that nonionic surfactants “Tritons” significantly increase the speed of membranolytic action of AMPs, and enhance their antibacterial activity.
Full Text
##article.viewOnOriginalSite##About the authors
M S Zharkova
Institute of Experimental Medicine, Saint Petersburg
D S Orlov
Institute of Experimental Medicine, Saint Petersburg
A A Kolobov
State Research Institute of Highly Pure Biopreparations, Saint Petersburg
O V Shamova
Institute of Experimental Medicine, Saint Petersburg
References
- Antibacterial peptide protocols / W. Shafer (ed.). Totowa, NJ: Humana Press Inc., 1998. 255 p.
- Orhan G, et al. Synergy Tests by E Test and Checkerboard Methods of Antimicrobial Combinations against Brucella melitensis. J. Clin. Microbiol. 2005;43(1):140-143.
- Lehrer R, et al. Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry. J. Immunol. Methods. 1988;108:153-158.
Supplementary files
