INFLUENCE OF SEMAX ON THE LEVEL OF INTERLEUKIN-1βIN THE CONDITIONS OF “SOCIAL” STRESS

A study on the effect of Semax on the level of interleukin-1β under conditions of “social” stress was performed on non-white white rats-males. The formation of a stress reaction under the conditions of “social” exposure was confirmed by the presence of a “stress triad”, including adrenal hypertrophy, a decrease in the number of eosinophils in the peripheral blood and the presence of erosive and ulcerative lesions of the gastric mucosa. The level of serum IL-1β was determined by the method of enzyme-linked immunosorbent assay (ELISA). “Social” stress, formed as a result of inter-male confrontations, is accompanied by an increase in cytokine production, manifested by an increase in the concentration of interleukin-1β. Against the background of Semax administration to stressed animals, we can speak of this representative from the group of neuropeptides, as a possible means of correction, contributing to a decrease in the level of IL-1β.

Semax, “social” stress, immune system, interleukin-1β