电邮这篇文章 Identification of a highly conserved region critical for the functionality of the CP190 protein in Drosophila melanogaster
- 作者: Melnikova L.S.1, Balagurov K.I.1, Georgiev P.G.1, Golovnin A.K.1
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隶属关系:
- Institute of Gene Biology, Russian Academy of Sciences
- 期: 卷 521, 编号 1 (2025)
- 页面: 229-234
- 栏目: Articles
- URL: https://ogarev-online.ru/2686-7389/article/view/306219
- DOI: https://doi.org/10.31857/S2686738925020115
- ID: 306219
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详细
The CP190 protein binds to both housekeeping gene promoters and insulator/boundary elements and plays a critical role in their activity. The aim of this work was to study the effect of deletions in highly conserved regions of the CP190 protein on its functionality. It was shown that deletion of the sequence from 664 to 700 aa leads to a lethal phenotype. Thus, a new region was identified in CP190 that plays an important role in the interaction of the CP190 protein with as yet unidentified partner proteins, stabilization of protein complexes formed by CP190 and their recruitment to chromatin.
作者简介
L. Melnikova
Institute of Gene Biology, Russian Academy of Sciences
Email: lsm73@mail.ru
Moscow, Russian Federation
K. Balagurov
Institute of Gene Biology, Russian Academy of Sciences
Email: lsm73@mail.ru
Moscow, Russian Federation
P. Georgiev
Institute of Gene Biology, Russian Academy of Sciences
Email: lsm73@mail.ru
Moscow, Russian Federation
A. Golovnin
Institute of Gene Biology, Russian Academy of Sciences
Email: lsm73@mail.ru
Moscow, Russian Federation
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