Observation of COVID-19-associated coagulopathy in a patient of ENT hospital

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Abstract

The article presents a clinical case of a patient of the otorhinolaryngology department of the Samara Clinical Hospital No. 8 who had a new coronavirus infection. Complications were manifested by primary thrombosis of the orbital veins, facial veins, followed by the spread of the process into the pterygoid plexus, veins of the nasal cavity and paranasal sinuses.

The study analyzes the dynamics of the clinical picture and compares it with the results of the postmortem examination.

Vascular thrombosis of the nasal cavity and paranasal sinuses during X-ray examination can manifest itself as a decrease in pneumatization of the sinuses with possible minor exudation due to ischemic changes in the mucous membrane. Thrombosis developing with underlying COVID-19-associated coagulopathy can have different initial localizations and are a formidable complication with a high mortality rate.

Patients who have undergone COVID-19 need to control the coagulogram not only during the illness, but also during the period of convalescence and early periods after recovery.

About the authors

Tatyana A. Zavalko

Samara State Medical University; Samara Clinical Hospital №8

Email: fzavalko@mail.ru
ORCID iD: 0000-0003-1955-6423

Head of the Otorhinolaryngology Department, PhD, assistant of the Otorhinolaryngology Department named after academician I.B. Soldatov

Russian Federation, Samara

Tatyana Y. Vladimirova

Samara State Medical University

Email: vladimirovalor@yandex.ru
ORCID iD: 0000-0003-1221-5589

PhD, Associate professor, Head of the Otorhinolaryngology Department and Clinic named after academician I.B. Soldatov

Russian Federation, Samara

Lyudmila A. Baryshevskaya

Samara State Medical University

Author for correspondence.
Email: baryshevskaya.ludmila@gmail.com
ORCID iD: 0000-0002-6536-8784

PhD, Associate professor, Otorhinolaryngology Department named after academician I.B. Soldatov

Russian Federation, Samara

Lyubov V. Fileva

Samara State Medical University

Email: s-amor@inbox.ru
ORCID iD: 0000-0001-6458-1914

assistant of the Otorhinolaryngology Department named after academician I.B. Soldatov

Russian Federation, Samara

Ekaterina D. Medvedeva

Samara State Medical University

Email: katemed96@gmail.com
ORCID iD: 0000-0001-9995-1006

Clinical Resident of the Department of Otorhinolaryngology named after academician I.B. Soldatov

Russian Federation, Samara

References

  1. Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J Med Virol. 2020;92(4):401-402. doi: 10.1002/jmv.25678
  2. Hui DS, E IA, Madani TA, Ntoumi F, Kock R, Dar O, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health – the latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020;91:264-6. doi: 10.1016/j.ijid.2020.01.009
  3. Temporary guidelines. Prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Version 8 from 03/09/20. Working group of authors. (In Russ.). [Временные методические рекомендации. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Версия 8 от 03.09.20. Рабочая группа авторов].
  4. Whyte CS, Morrow GB, Mitchell JL, Chowdary P, Mutch NJ. Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19. J Thromb Haemost. 2020;18(7):1548-1555. doi: 10.1111/jth.14872
  5. Idell S, James KK, Levin EG, et al. Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989;84(2):695-705. doi: 10.1172/JCI114217
  6. Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844-847. doi: 10.1111/jth.14768
  7. Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020;191:145-147. doi: 10.1016/j.thromres.2020.04.013
  8. Haimei MA. Pathogenesis and Treatment Strategies of COVID-19-Related Hypercoagulant and Thrombotic Complications. Clinical and Applied Thrombosis / Hemostasis. 2020;26:1-5. doi: 10.1177/1076029620944497
  9. Spiezia L, Boscolo A, Poletto F, et al. COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure. Thromb Haemost. 2020;120(6):998-1000. doi: 10.1055/s-0040-1710018
  10. Zhai Z, Li C, Chen Y, et al. Prevention and treatment of venous thromboembolism associated with coronavirus disease 2019 infection: a consensus statement before guidelines. Thromb Haemost. 2020;120(6):937-948. doi: 10.1055/s-0040-1710019
  11. Галстян Г.М. Коагулопатия при COVID-19. Пульмонология. 2020;30(5):645-657. doi: 10.18093/0869-0189-2020-30-5-645-657
  12. Lobastov KV, Schastlivtsev IV, Porembskaya OYa, et al. COVID-19-associated coagulopathy: an overview of current guidelines for diagnosis, treatment and prevention. Inpatient replacement technologies: Outpatient surgery. 2020;(3-4). (In Russ.). [Лобастов К.В., Счастливцев И.В., Порембская О.Я. и др. COVID-19-ассоциированная коагулопатия: обзор современных рекомендаций по диагностике, лечению и профилактике. Стационарозамещающие технологии: Амбулаторная хирургия. 2020;(3-4)]. doi: 10.21518/1995-1477-2020-3-4
  13. Cattaneo M, Bertinato EM, Birocchi S, et al. Pulmonary embolism or pulmonary thrombosis in COVID-19? Is the recommendation to use high-dose heparin for thromboprophylaxis justified? Thromb Haemost. 2020. doi: 10.1055/s-0040-1712097
  14. Harapan H, Itoh N, Yufika A. Coronavirus disease 2019 (COVID-19). A literature review. J Infect Public Health. 2020 May;13(5):667-673. doi: 10.1016/j.jiph.2020.03.019
  15. Levi M, Thachil J, Iba T, Levy JH. Coagulation abnormalities and thrombosis in patients with COVID-19. Lancet Haematol. 2020;7(6):438-440. doi: 10.1016/S2352-3026(20)30145-9

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Copyright (c) 2021 Zavalko T.A., Vladimirova T.Y., Baryshevskaya L.A., Fileva L.V., Medvedeva E.D.

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