Email this article New clinically relevant biochemical and functional markers in neonatology
- Authors: Zakharova L.I.1, Pechkurov D.V.1, Poretskova G.Y.1, Koltsova N.S.1
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Affiliations:
- Samara State Medical University
- Issue: Vol 4, No 1 (2019)
- Pages: 48-52
- Section: Paediatrics
- URL: https://ogarev-online.ru/2500-1388/article/view/43762
- DOI: https://doi.org/10.35693/2500-1388-2019-4-1-48-52
- ID: 43762
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Abstract
Objectives – to identify the markers of liver functional maturation, the dynamics of the cyclic nucleotide in blood plasma, the indicators of cerebral hemodynamics in premature infants during the early and late neonatal periods.
Material and methods. The study included 330 premature infants of 26th – 37th weeks of gestation, examined in early and late neonatal periods. There were 3 groups profiled according to the type of leading pathology – respiratory distress syndrome (RDS) (group I, included 80 children), newborn jaundice and edema syndrome (group II, included 80 children), intraventricular hemorrhage Grade1 (IVH Grade1) (group III, consisted of 46 children). The groups in the study were matched by 3 comparison groups of 124 healthy preterm infants.
Results. The clinical significance of the first assayed quantitative indicators of AFP, serum albumin system, cyclic nucleotides, plasma fibronectin in conditionally healthy children of different gestation periods is discussed. The scientific credence was given to pathogenetic role of deviations of these indicators in the development of RDS (the decrease in cAMP, the increase in cGMP, the decrease in ratio cAMP/cGMP); in jaundice and edema syndromes (the increased AFP, the reduction in effective serum albumin concentration (EAC) and overall serum albumin concentration (OAC)), IVH grade 1 (the reduction of plasma fibronectin, and the blood flow speed in vein of Galen according to neurosonography with with Doppler measurements (NSDG) in the first days of life).
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##article.viewOnOriginalSite##About the authors
Lyudmila Igorevna Zakharova
Samara State Medical University
Author for correspondence.
Email: kdbsamgmu@yandex.ru
ORCID iD: 0000-0002-3367-3573
PhD, Professor of the Department of Childhood Diseases of SamSMU
Russian Federation, SamaraDmitrii V. Pechkurov
Samara State Medical University
Email: dmpechkurov@yandex.ru
ORCID iD: 0000-0002-5869-2893
PhD, Professor, Head of the Department of Childhood Diseases of SamSMU
Russian Federation, SamaraGalina Yu. Poretskova
Samara State Medical University
Email: vra4_pediatr@mail.ru
ORCID iD: 0000-0002-3131-1368
Associate Professor, Department of Childhood Diseases of SamSMU
Russian Federation, SamaraNadezhda S. Koltsova
Samara State Medical University
Email: kdbsamgmu@yandex.ru
PhD, Associate Professor of the Department of Childhood Diseases of SamSMU
Russian Federation, SamaraReferences
- Захарова Л.И., Печкуров Д.В., Кольцова Н.С. Амбулаторная неонатология: формирование здоровья ребенка первого года жизни. Практическое руководство для врачей-педиатров. М., Медпрактика, 2014. [Zakharova LI, Pechkurov DV, Kol'tsova NS. Ambulatornaya neonatologiya: formirovanie zdorov'ya rebenka pervogo goda zhizni. Prakticheskoe rukovodstvo dlya vrachey-pediatrov. M., Medpraktika, 2014. (In Russ.)].
- Избранные клинические рекомендации по неонатологии. Под ред. Байбариной Е.Н., Дегтярева Е.Н. М., ГЭОТАР-Медиа, 2016. [Izbrannye klinicheskie rekomendatsii po neonatologii. Ed. Baybarina EN, Degtyarev EN. M., GEOTAR-Media, 2016. (In Russ.)].
- Захарова Л.И., Кольцова Н.С., Тупикова С.А., Куликова Н.И. Недоношенный ребенок – мультидисциплинарная проблема и особенности ее решения на современном этапе. Практическая медицина. 2016;8(100):19–22. [Zakharova LI, Kol'tsova NS, Tupikova SA, Kulikova NI. Premature newborn as a multidisciplinary problem and its solution at the present stage. Prakticheskaya meditsina. 2016;8(100):19–22. (In Russ.)].
- Захарова Л.И., Кольцова Н.С., Тупикова С.А. Причины танатогенеза недоношенных детей с экстремально и очень низкой массой тела в раннем неонатальном периоде по данным перинатального центра. Вопросы практической педиатрии. 2010;5(1):24. [Zakharova LI, Kol'tsova NS, Tupikova SA. Causes of thanatogenesis in early neonatal period in preterm extremely low and very low birthweight infants: perinatal center statistics. Voprosy prakticheskoy pediatrii. 2010;5(1):24. (In Russ.)].
- Порецкова Г.Ю., Захарова Л.И. и др. Белково-синтетическая функция печени недоношенных новорожденных. Материалы IX Конгресса педиат-ров России «Актуальные проблемы педиатрии»; Февраль 10-12, 2004; Москва. [Poretskova GYu, Zakharova LI et al. Belkovo-sinteticheskaya funktsiya pecheni nedonoshennykh novorozhdennykh. Materialy IX Kongressa pediatrov Rossii "Aktual'nye problemy pediatrii"; February' 10-12, 2004; Moscow. (In Russ.)]. https://cyberleninka.ru/article/n/materialy-ix-kongressa-pediatrov-rossii-aktualnye-problemy-pediatrii-moskva-10-12-fevralya-2004-g
- Захарова Л.И., Ярцева И.Н. Метилксантиновые производные в лечении РДС у недоношенных детей. Вопросы практической педиатрии. 2008;3(5):58–59. [Zakharova LI, Yartseva IN. Methyl xanthine derivatives in treatment of RDS in premature infants. Voprosy prakticheskoy pediatrii. 2008;3(5):58–59. (In Russ.)].
- Ярцева И.Н., Захарова Л.И. Ранние исходы РДС у недоношенных детей при разных вариантах лечения. Вопросы практической педиатрии. 2008;3(5):59. [Yartseva IN, Zakharova LI. RDS early outcomes in premature infants with different types of treatment. Voprosy prakticheskoy pediatrii. 2008;3(5):59. (In Russ.)].
- Тупикова С.А., Захарова Л.И. Особенности мозгового кровотока у глубоко недоношенных детей в динамике раннего неонатального периода. Медицинский альманах. 2014;2 (32):111–114. [Tupikova SA, Zakharova LI. The peculiarities of cerebral blood flow of small premature infants in the dynamics of the early neonatal period. Meditsinskiy al'manakh. 2014;2 (32):111–114. (In Russ.)].
- Тупикова С.А., Захарова Л.И. Обоснование программы прогнозирования развития ВЖК у глубоко недоношенных детей. Международный журнал прикладных и фундаментальных исследований. 2015;2(9): 297. [Tupikova SA, Zakharova LI. The predict program for the risk of IHV in very early barked infants. Mezhdunarodnyy zhurnal prikladnykh i fundamental'nykh issledovaniy. 2015;2(9): 297. (In Russ.)].
- Захарова Л.И., Тупикова С.А. Возможности нейропротективной терапии в перинатологии. Ульяновский медико-биологический журнал. 2017; 3:62–71. [Zakharova LI, Tupikova SA. Opportunities of neuroprotective therapy for perinatology. Ul'yanovskiy mediko-biologicheskiy zhurnal. 2017; 3:62–71. (In Russ.).]
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