GENERATION OF IL-17 IMMUNE RESPONSE IN OBESE PATIENTS WITH ASTHMA


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Abstract

Aim - to investigate the influence of IL-17, IL-10 on the level of asthma control among obese patients. Materials and methods. 79 patients with asthma aged from 18 to 65 years were enrolled in our study and categorized into three groups according to their body mass index (BMI): group 1 - normal BMI (27 (34,2%) patients, age 50±13,8), group 2 - overweight (28 (35,4%) patients, age 44±16,5) and group 3 - obese (24 patients (30,4%), age 57,3±8,2). These patients underwent spirometry and were compared for clinical characteristics, plasma level of IL-17 and IL-10 using ELISA assay. Results. IL-17 concentrations were higher in the obese and uncontrolled asthmatics. Statistically significant correlation between the level of IL-10 and BMI was not found. Conclusions. Our study shows that cytokines IL-17 play an important role in the immune response of asthma in obese patients, and represent an important therapeutic target for the asthma treatment.

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About the authors

MS S Nurdina

Samara State Medical University

Email: Goremykina_marya@mail.ru
PhD student, Department of family medicine, Samara State Medical University. ap. 22, 54 Vladimirskaya st., Samara Russia, 443089

VI I Kupaev

Samara State Medical University

Email: vk1964sam@rambler.ru
PhD, Professor, head of the Department of family medicine, Samara State Medical University.

OV V Sazonova

Samara State Medical University

Email: Ov_2004@mail.ru
PhD, associate professor, head of the Institute of hygiene and human ecology, Samara State Medical University.

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Copyright (c) 2017 Nurdina M.S., Kupaev V.I., Sazonova O.V.

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