BIOPHYSICAL BASES OF GENOME ORGANIZATION


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Abstract

Aim - the analysis of nucleotide sequences of DNA molecules and the bases of the information storage with the help of DNA. Material and methods - the study is based on Markov chain theory and Bayesian Information Criterion. Results. Principles of genetic code construction were investigated. Specific nucleotide sequences were analyzed using Markov chain theory; the method of sequencing nucleotide sequences was described. Conclusion. A nucleotide sequence has certain restrictions associated with complementarity of the bases along DNA chain. These restrictions at the level of triplet sequence can be eliminated by degeneracy of the genetic code.

About the authors

AN N Volobuev

Samara State Medical University

Email: volobuev47@yandex.ru
PhD, Professor, head of the Department of medical physics, mathematics and informatics, Samara State Medical University. postbox 1423, Samara, Russia, 443079

ES S Petrov

Samara State Medical University

Email: petroves@inbox.ru
PhD, Associate Professor, associate professor of the Department of operative surgery and topographical anatomy with the course of innovative technologies, Samara State Medical University.

NP P Romanchuk

Samara State Medical University

Email: romanchuknp@mail.ru
post-graduate student of the Department of physiology with the course of health and safety and disaster medicine, Samara State Medical University.

References

  1. Ленинджер А. Биохимия. Молекулярные основы структуры и функций клетки. М.: Мир, 1974.
  2. Уотсон Дж. Молекулярная биология гена. М.: Мир, 1978
  3. Gamov GA. Possible Relation between Deoxyribonucleic Acid and Protein Structures. Nature 173 Feb 13(1954):318
  4. Резерфорд А. Биография жизни. От первой клетки до генной инженерии. М.: БИНОМ. Лаборатория знаний, 2016
  5. Козлов Н.Н. Математический анализ генетического кода. М.: БИНОМ, 2015
  6. Brown D., Rothery P. Models in Biology: Mathematics, Statistics, and Computing. Jon Wiley & Sons Ltd., Chichester, NY, 1994
  7. Вейр Б. Анализ генетических данных. М: Мир, 1995

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Copyright (c) 2017 Volobuev A.N., Petrov E.S., Romanchuk N.P.

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