The effect of thick hawthorn extracts on kidney

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Abstract

Aim – to study the effect of the hawthorn shoots on kidney excretory function.

Material and methods. We used the shoots of Crataegus sanguinea Pall., Crataegus monogina Jacq. and Crataegus submollis Sarg. harvested during the flowering period in the arboretum of the Botanical Garden of Samara University in 2021. The raw material of each type, separately, was used in fractional maceration with 70% ethyl alcohol for creation liquid extracts, then, after extractant removal, the thick extracts were obtained. The thick extracts were processed with differential spectrophotometry method to calculate the total of flavonoids in terms of hyperoside. The diuretic effect of hawthorn thick extracts was evaluated during a chronic experiment on white mongrel rats at a dose of 10 mg/kg.

Results. It was found that thick extracts of the shoots of Crataegus sanguinea Pall. and Crataegus submollis Sarg. effect on diuresis and creatinin excretion, while the thick extract of Crataegus monogina Jacq. did not affect the excretory function of the kidneys.

Conclusion. The shoots of Crataegus sanguinea Pall. and Crataegus submollis Sarg., harvested in the flowering period, can serve as a raw material for drugs for enhancing the excretory function of the kidneys. Crataegus submollis Sarg. can serve as a medicinal plant, along with other types of hawthorn.

About the authors

Vladmir A. Kurkin

Samara State Medical University

Author for correspondence.
Email: v.a.kurkin@samsmu.ru
ORCID iD: 0000-0002-7513-9352

PhD, Professor, Head of the Department of Pharmacognosy with botany and the basics of phytotherapy

Russian Federation, Samara

Nadezhda A. Volkova

Samara State Medical University

Email: n.a.volkova@samsmu.ru
ORCID iD: 0000-0002-7820-7074

a postgraduate student of the Department of Pharmacognosy with botany and the basics of phytotherapy

Russian Federation, Samara

Olga E. Pravdivtseva

Samara State Medical University

Email: o.e.pravdivtseva@samsmu.ru
ORCID iD: 0000-0003-3318-3168

PhD, Professor, Department of Pharmacognosy with botany and the basics of phytotherapy

Russian Federation, Samara

Elena N. Zaitceva

Samara State Medical University

Email: e.n.zaitceva@samsmu.ru
ORCID iD: 0000-0001-5689-2077

PhD, Associate professor, Head of the Department of pharmacology n.a. Honored Scientist of the Russian Federation

Russian Federation, Samara

Anastasiya S. Tsibina

Samara State Medical University

Email: a.s.tsibina@samsmu.ru
ORCID iD: 0000-0002-0384-5522

PhD, assistant of the Department of pharmacology n.a. Honored Scientist of the Russian Federation the professor A.A. Lebedev

Russian Federation, Samara

Anastasiya I. Klimova

Samara State Medical University

Email: nastya9622@mail.ru
ORCID iD: 0000-0003-2287-1192

postgraduate student of the Department of pharmacology n.a. Honored Scientist of the Russian Federation the professor A.A. Lebedev

Russian Federation, Samara

References

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  4. Kurkin VA, Pravdivceva OE, Shajkhutdinov IKh, et al. Species of the genus hawthorn (Crataegus L.): standardization and creation of medicines. Samara, 2020. (In Russ.). [Куркин В.А., Правдивцева О.Е., Шайхутдинов И.Х., и др. Виды рода боярышник (Crataegus L.): стандартизация и создание лекарственных препаратов. Самара, 2020].
  5. Zilfikarov IN. Natural medicines: chemical composition and standardization. M., 2021. (In Russ.). [Зилфикаров И.Н. Природные лекарственные препараты: химический состав и стандартизация. М., 2021].
  6. European Pharmacopoeia. – 8 ed. Strasbourg: Directorate for the Quality of Medicines & HealthCare of the Council of Europe, 2013.

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Copyright (c) 2022 Kurkin V.A., Volkova N.A., Pravdivtseva O.E., Zaitceva E.N., Tsibina A.S., Klimova A.I.

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