Difficulties in differential diagnosis of preeclampsia and acute surgical pathology
- Authors: Kaganova M.A.1, Spiridonova N.V.1, Artyukh Y.A.1, Denisova N.G.2, Katkov S.S.2, Antropov I.V.2, Yakovleva M.A.1
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Affiliations:
- Samara State Medical University
- Samara City Clinical Hospital № 1 named after N.I. Pirogov
- Issue: Vol 24, No 2 (2024)
- Pages: 4-10
- Section: OBSTETRICS AND GYNECOLOGY
- URL: https://ogarev-online.ru/2410-3764/article/view/280508
- DOI: https://doi.org/10.35693/AVP626990
- ID: 280508
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Abstract
Aim – to determine the prevalence of preeclampsia and HELLP syndrome among patients hospitalized in surgical departments with complaints of pain in the epigastrium, right hypochondrium and/or nausea and vomiting.
Material and methods. An analysis was carried out of visits of pregnant women over 20 weeks to the surgical department in 2023 and 42 cases of hospitalization of pregnant patients with suspected acute surgical pathology hospitalized in surgical departments No. 6 and No. 7 of the Samara City Clinical Hospital No. 1 named after N.I. Pirogov. The following parameters were assessed: age, gestational age, complaints at the time of admission, general blood and urine test data, the condition of the fetus according to ultrasound, Doppler ultrasound, CTG, presence of obstetric and gynecological pathology and somatic diseases.
Results. Patients with acute appendicitis (7 out of 42 pregnant women) were excluded from the study. Of the remaining 35 patients, the diagnosis of severe preeclampsia, HELLP syndrome was made in 3 cases (8.6%), in 2 cases, gestational hypertension or protineria (5.7%) – the main group. Cholelithiasis, acute cholecystitis – in 2 cases (5.7%), in other cases the diagnosis of acute pancreatitis was made – 28 patients (80.0%). The work provides a comparison of clinical and laboratory parameters of patients in two groups, with obstetric and surgical pathology. A clinical case of a combination of severe PE with the development of HELLP-syndrome and cholecystitis is also presented.
Conclusions. Differential diagnosis between obstetric complications such as PE and HELLP-syndrome and acute surgical pathology still remains a pressing interdisciplinary problem. Severe forms of PE can take the form of acute pancreatitis, acute cholecystitis, or other diseases. According to the results of our observation, this phenomenon occurred in 15% of patients hospitalized in surgical departments. Only timely diagnosis allows choosing adequate routing and specialized care for this complication.
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##article.viewOnOriginalSite##About the authors
Mariya A. Kaganova
Samara State Medical University
Author for correspondence.
Email: mkaganova@yandex.ru
ORCID iD: 0000-0001-5879-418X
PhD, Associate professor of the Department of Obstetrics and Gynecology of Institute of Postgraduate Education
Russian Federation, SamaraNatalya V. Spiridonova
Samara State Medical University
Email: nvspiridonova@mail.ru
ORCID iD: 0000-0003-3390-8034
PhD, Professor, Head of the Department of Obstetrics and Gynecology of Institute of Postgraduate Education
Russian Federation, SamaraYuliya A. Artyukh
Samara State Medical University
Email: artyyuliya@yandex.ru
ORCID iD: 0000-0002-3248-5810
PhD, assistant of the Department of Obstetrics and Gynecology of Institute of Postgraduate Education
Russian Federation, SamaraNatalya G. Denisova
Samara City Clinical Hospital № 1 named after N.I. Pirogov
Email: denisov_a_nata@mail.ru
PhD, Head of the 20th obstetric department
Russian Federation, SamaraSergei S. Katkov
Samara City Clinical Hospital № 1 named after N.I. Pirogov
Email: Sskat1982@mail.ru
Head of the 7th surgical department
Russian Federation, SamaraIgor V. Antropov
Samara City Clinical Hospital № 1 named after N.I. Pirogov
Email: a1973iv@yandex.ru
Head of the 6th surgical department
Russian Federation, SamaraMariya A. Yakovleva
Samara State Medical University
Email: mariayakovleva99@mail.ru
ORCID iD: 0000-0002-0137-5045
resident of the Department of Obstetrics and Gynecology of the Institute of Postgraduate Education
Russian Federation, SamaraReferences
- Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin Summary, Number 222. Obstet Gynecol. 2020;135(6):1492-1495. DOI: https://doi.org/10.1097/AOG.0000000000003892
- Clinical recommendations. Preeclampsia. Eclampsia. Edema, proteinuria and hypertensive disorders during pregnancy, childbirth and the postpartum period. 2021. (In Russ.) [Клинические рекомендации. Преэклампсия. Эклампсия. Отеки, протеинурия и гипертензивные расстройства во время беременности, в родах и послеродовом периоде. 2021].
- Khodzhaeva ZS, Kogan EA, Klimenchenko NI, et al. Clinical and pathogenetic features of early and late preeclampsia. Obstetrics and gynecology. 2015;1. (In Russ.). [Ходжаева З.С., Коган Е.А., Клименченко Н.И., и др. Клинико-патогенетические особенности ранней и поздней преэклампсии. Акушерство и гинекология. 2015;1]. URL: https://aig-journal.ru/articles/Kliniko-patogeneticheskie-osobennosti-rannei-i-pozdnei-preeklampsii.html
- Savelyeva GM, Krasnopolsky VI, Strizhakov AN, et al. To what classification of gestosis (preeclampsia) should adhere a doctor in daily work? Journal of Obstetrics and Women's Diseases. 2013;62(1):5-9. [Савельева Г.М., Краснопольский В.И., Стрижаков А.Н., и др. Какой классификации гестозов (преэклампсии) должен придерживаться врач в повседневной работе? Журнал акушерства и женских болезней. 2013;62(1):5-9]. DOI: https://doi.org/10.17816/JOWD6215-9
- Douglas KA, Redman CW. Eclampsia in the United King dom. Br Med J. 1994;309:1395-1400. DOI: https://doi.org/10.1136/bmj.309.6966.1395
- Haram K, Svendsen E, Abildgaard U. The HELLP syndrome: clinical issues and management. BMC Pregnancy Childbirth. 2009;9:8. DOI: https://doi.org/10.1186/1471-2393-9-8
- Mayama M, Uno K, Tano S, et al. Incidence of posterior reversible encephalopathy syndrome in eclamptic and patients with preeclampsia with neurologic symptoms. American Journal of Obstetrics and Gynecology. 2016;215(2):239.e1-239.e5. DOI: https://doi.org/10.1016/j.ajog.2016.02.039
- American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122(05):1122-1131. DOI: https://doi.org/10.1097/01.AOG.0000437382.03963.88
- Kai-Jung Chang, Kok-Min Seow, Kuo-Hu Chen. Preeclampsia: Recent Advances in Predicting, Preventing, and Managing the Maternal and Fetal Life-Threatening Condition. Int J Environ Res Public Health. 2023;20(4):2994. DOI: https://doi.org/10.3390/ijerph20042994
- Dusse LM, Alpoim PN, Silva JT, et al. Revisiting HELLP syndrome. Clinica Chimica Acta. 2015;451:117-120. DOI: https://doi.org/10.1016/j.cca.2015.10.024
- Makatsaria AD. Thrombotic microangiopathies in obstetric practice. M., 2017. (In Russ.). [Макацария А.Д. Тромботические микроангиопатии в акушерской практике. М., 2017].
- Bykov AS, Martirosyan S, Ababkov SG, et al. Tactics for managing patients with eclampsia: what can we do today? Status praesens. Gynecology, obstetrics, infertile marriage. 2021;(81):45-51. (In Russ.). [Быков А.С., Мартиросян С.В., Абабков С.Г., и др. Тактика ведения пациенток с эклампсией: что мы можем сегодня? Status praesens. Гинекология, акушерство, бесплодный брак. 2021;5(81):45-51]. URL: https://praesens.ru/files/2021/magazine/SP81_demo.pdf
- Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222. Obstet Gynecol. 2020;135(6):e237-e260. DOI: https://doi.org/10.1097/AOG.0000000000003891
- Erez O, Romero R, Jung E, et al. Preeclampsia and eclampsia: the conceptual evolution of a syndrome. Am J Obstet Gynecol. 2022;226(2S):S786-S803. DOI: https://doi.org/10.1016/j.ajog.2021.12.001
- Vollaard E, Zeeman G, Alexander JA, et al. “Delta eclampsia” – a hypertensive encephalopathy of pregnancy in “normotensive” women. Am J Obstet Gynecol. 2007;197:S140. DOI: https://doi.org/10.1016/j.ajog.2007.10.552
- Fishel Bartal M, Sibai BM. Eclampsia in the 21st century. Am J Obstet Gynecol. 2022;226(2S):S1237-S1253. DOI: https://doi.org/10.1016/j.ajog.2020.09.037
- Feleshtynskyi IP, Pavliv TP. Algorithm for acute pancreatitis diagnostics and treatment in pregnant women. Journal of Education, Health and Sport. 2023;42(1):130-139. DOI: http://dx.doi.org/10.12775/JEHS.2023.42.01.012
- Raio L, Bersinger NA, Malek A, et al. Ultra-high sensitive C-reactive protein during normal pregnancy and in preeclampsia: a pilot study. J Hypertens. 2019;37(5):1012-1017. DOI: https://doi.org/10.1097/HJH.0000000000002003
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