Email this article Development of suppositories based on aloe arborescens juice
- Authors: Glushchenko S.N.1, Shmygareva A.A.1, Sankov A.N.1
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Affiliations:
- Orenburg State Medical University
- Issue: Vol 20, No 1-2 (2020)
- Pages: 126-130
- Section: Pharmacy
- URL: https://ogarev-online.ru/2410-3764/article/view/54528
- ID: 54528
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Abstract
Introduction. The aim of this work is to develop an effective herbal medicine based on Aloe arborescens juice (Aloe arborescens Mill.) with a high content of active substances. It allows to use this drug for patients suffering from hemorrhoids, as well as to develop methods for the standardization of this dosage form.
Material and methods. Homeopathic suppositories of Aloe DN (containing aloe, rhubarb and chamomile) are recommended by the state registry of medicines for the treatment of chronic constipation. This medicine having some drawbacks, we are the first to develop suppositories with aloe juice containing high level of active substances, in which selected hydrophilic base contributes to the rapid absorption of active substances.
Results and discussion. The advantages of the developed method for producing suppositories with Aloe arborescens juice are as follows: the content of active substances in one suppository on a hydrophilic base (gelatin-glycerol) determined by the UV spectrophotometry method is 2.6 mg, it ensures the optimal pharmacological effect; hydrophilic base, from which the active ingredients of Aloe arborescens juice (barbaloin) are easily absorbed, allows to recommend the use of this dosage form to people with hemorrhoids.
Conclusions. The dosage form of hydrophilic suppositories with Aloe arborescens juice provides a high release of the active substance from the base. This substance is easily absorbed into the rectum and exerts laxative effect. The proposed dosage form is of therapeutic benefit due to the higher concentration of active substances in Aloe arborescens juice (2.6 mg).
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##article.viewOnOriginalSite##About the authors
Svetlana N. Glushchenko
Orenburg State Medical University
Author for correspondence.
Email: svetlana94g@gmail.com
Postgraduate student, Department of Management and Economy of Pharmacy, Pharmaceutical Technology and Pharmacognozy
Russian Federation, OrenburgAnna A. Shmygareva
Orenburg State Medical University
Email: a.shmygareva@mail.ru
Doctor of Pharmaceutical Sciences, Professor, Department of Management and Economy of Pharmacy, Pharmaceutical Technology and Pharmacognozy
Russian Federation, OrenburgAnatoly N. Sankov
Orenburg State Medical University
Email: a.n.sankov@mail.ru
Candidate of Medical Sciences, Associate Professor, Department of Management and Economy of Pharmacy, Pharmaceutical Technology and Pharmacognozy
Russian Federation, OrenburgReferences
- Государственный реестр лекарственных средств: официальное издание (по состоянию на 01 апреля 2009 г.). Т. 1 – М.: Медицинский совет, 2008. [Gosudarstvenny reestr lekarstvennykh sredstv: ofitsial’noye izdaniye (po sostoyaniyu na 01 aprelya 2009 g.). Vol. 1. Moscow: Meditsinskiy sovet; 2008. (In Russ.)]
- Государственная фармакопея Российской Федерации. Вып. 2. XIV изд. – М.: Медицина, 2018. [Gosudarstvennaya farmakopeya Rossiiskoy Federatsii. Issue 2. XIV ed. Moscow: Meditsina; 2018. (In Russ.)]
- Государственная фармакопея Российской Федерации. Вып. 4. XIV изд. – М.: Медицина, 2018. [Gosudarstvennaya farmakopeya Rossiiskoy Federatsii. Issue 4. XIV ed. Moscow: Meditsina; 2018. (In Russ.)]
- Куркин В.А. Фармакогнозия: учебник для студентов фармацевтических вузов. Изд. 2-е, перераб. и доп. – Самара: Офорт, 2007. – 1239 с. [Kurkin VA. Farmakognoziya: uchebnik dlya studentov farmatsevticheskikh vuzov. 2nd revised and updated. Samara: Ofort; 2007. 1239 p. (In Russ.)]
- Куркин В.А. Основы фитотерапии: учебное пособие для студентов фармацевтических вузов. – Самара: Офорт, 2009. – 963 с. [Kurkin VA. Osnovy fitoterapii: uchebnoe posobie dlya studentov farmatsevticheskikh vuzov. Samara: Ofort; 2009. 963 p. (In Russ.)]
- Муравьева Д.А., Самылина И.А., Яковлев Г.П. Фармакогнозия: учебник. – М.: Медицина, 2002. – 656 с. [Murav’eva DA, Samylina IA, Yakovlev GP. Farmakognoziya: uchebnik. Moscow: Meditsina; 2002. 656 p. (In Russ.)]
- Чуешов В.И., Чернов М.Ю., Хохлова Л.М., и др. Промышленная технология лекарств: учебник для студентов высших учебных заведений. В 2 т. Т. 2. – Харьков: НФАУ МТК-Книга, 1999. – 704 с. [Chueshov VI, Chernov MYu, Khokhlova LM, et al. Promyshlennaya tekhnologiya lekarstv: uchebnik dlya studentov vysshikh uchebnykh zavedenii. Vol. 2. Khar’kov: NFAU MTK-Kniga; 1999. 704 p. (In Russ.)]
- Куркин В.А., Шмыгарева А.А. Определение антраценпроизводных в коре крушины // Фармация. – 2010. – № 8. – С. 9–12. [Kurkin VA, Shmygareva AA. Determination of anthracene derivatives in the buckthorn (frangula) bark. Farmatsiia. 2010;(8):9-12. (In Russ.)]
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