Email this article Markers of inflammation in the oral fluid of patients in need of dental prosthetics
- Authors: Kartashov V.V.1, Nesterov A.M.1, Selezneva I.A.1
-
Affiliations:
- Samara State Medical University
- Issue: Vol 25, No 1 (2025)
- Pages: 69-72
- Section: DENTISTRY
- URL: https://ogarev-online.ru/2410-3764/article/view/291091
- DOI: https://doi.org/10.35693/AVP659813
- ID: 291091
Cite item
Full Text
Abstract
Aim – to evaluate markers of the inflammatory process in the oral fluid of patients in need of orthopedic dental care.
Material and methods. A study of dental status was conducted, determining the DMFT (Decayed, Missing, Filled Teeth) index and the Green – Vermillion index in 40 individuals, 20 of whom were in the control group and 20 were patients requiring dental orthopedic care. Assessments were made during the initial consultation and after hygiene measures. Cytokine response indicators, viz. IL-1, IL-6, and immunoglobulin A, were determined using ELISA. CRP (C-reactive protein) levels were assessed using the Cobas Integra+ automatic biochemical analyzer (Roche). Statistical analysis included both parametric and non-parametric methods.
Results. When comparing the data from the control group and patients requiring dental prosthetics before sanitation, deviations were detected in CRP levels, more than 4 times higher, and IL-1, 158% higher. After sanitation and hygiene measures, the most pronounced changes were observed in CRP levels, with a 70.5% reduction.
Conclusions. Deviations in the levels of pro-inflammatory cytokines in oral fluid can serve as indicators of the risk of developing inflammatory processes in the body. The level of CRP in oral fluid is a reliable and rapidly responsive indicator of adequate anti-inflammatory therapy.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Vladislav V. Kartashov
Samara State Medical University
Author for correspondence.
Email: stomkvv@gmail.com
ORCID iD: 0000-0002-8671-2898
MD, postgraduate student of the Department of Orthopedic Dentistry
Russian Federation, SamaraAleksandr M. Nesterov
Samara State Medical University
Email: nesterov003@rambler.ru
ORCID iD: 0000-0001-8487-7392
MD, Dr. Sci. (Medicine), Professor, Head of the Department of Orthopedic Dentistry
Russian Federation, SamaraInna A. Selezneva
Samara State Medical University
Email: Innola@mail.ru
ORCID iD: 0000-0001-6647-5330
MD, Dr. Sci. (Medicine), Associate Professor, Professor of the Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics
Russian Federation, SamaraReferences
- Hassaneen M, Maron JL. Salivary diagnostics in pediatrics: applicability, translatability, and limitations. Frontiers in Public Health. 2017;5:83. doi: 10.3389/fpubh.2017.00083
- Cruz-Almeida Y, Aguirre M, Sorenson H, et al. Age differences in salivary markers of inflammation in response to experimental pain: Does Venipuncture matter? Journal of Pain Research. 2017;10:2365-2372. doi: 10.2147/JPR.S138460
- Zalewska A, Waszkiewicz N, López-Pintor RM. The use of saliva in the diagnosis of oral and systemic diseases. Disease Markers. 2019:9149503. doi: 10.1155/2019/9149503
- Almerich-Silla JM, Montiel-Company JM, Pastor S, et al. Oxidative stress parameters in saliva and its association with periodontal disease and types of bacteria. Disease Markers. 2015:653537. doi: 10.1155/2015/653537
- Slavish DC, Graham-Engeland JE, Smyth JM, et al. Salivary markers of inflammation in response to acute stress. Brain Behav Immun. 2015;44:253-269. doi: 10.1016/j.bbi.2014.08.008
- Isaza-Guzmán DM, Cardona-Vélez N, Gaviria-Correa DE, et al. Association study between salivary levels of interferon (IFN)-gamma, interleukin (IL)-17, IL-21, and IL-22 with chronic periodontitis. Archives of Oral Biology. 2015;60(1):91-99. doi: 10.1016/j.archoralbio.2014.09.002
- Marques CP, Victor EC, Franco MM, et al. Salivary levels of inflammatory cytokines and their association to periodontal disease in systemic lupus erythematosus patients. A case-control study. Cytokine. 2016;85:165-170. doi: 10.1016/j.cyto.2016.06.025
- Rodríguez-Rabassa M, López P, Rodríguez-Santiago RE, et al. Cigarette smoking modulation of saliva microbial composition and cytokine levels. International Journal of Environmental Research and Public Health. 2018;15(11):2479. doi: 10.3390/ijerph15112479
- Mizuhashi F, Koide K, Toya S, et al. Levels of the antimicrobial proteins lactoferrin and chromogranin in the saliva of individuals with oral dryness. J Prosthet Dent. 2015;113(1):35-38. doi: 10.1016/j.prosdent.2013.12.028
- Truba TN, Doan J, Currie CL, et al. Short-term changes in daily movement behaviour influence salivary C-reactive protein in healthy women. Applied Physiology, Nutrition, and Metabolism. 2018;43(8):854-856. doi: 10.1139/apnm-2017-0758
- Nam Y, Kim Y-Y, Chang J-Y, et al. Salivary biomarkers of inflammation and oxidative stress in healthy adults. Archives of Oral Biology. 2019;97:215-222. doi: 10.1016/j.archoralbio.2018.10.026
- Svetlakova EN, Sementsova EA, Polushina LG, et al. On the issue of diagnosis of periodontal disease: Current capabilities and clinical needs. Health and Education millennium. 2017;19(3):34-37. [Светлакова Е.Н., Семенцова Е.А., Полушина Л.Г., и др. К вопросу диагностики пародонтита: существующие возможности и клинические потребности. Здоровье и образование в XXI веке. 2017;19(3):34-37]. doi: 10.26787/nydha-2226-7425-2017-19-3-34-37
- Perova NYu, Vinichenko EL, Bondarenko NA. The study of medication iicopid’s immunotropic effect in parodental inflammatory process’s combined treatment. International journal of applied and fundamental research. 2015;3:639-642. (In Russ.). [Перова Н.Ю., Виниченко Е.Л., Бондаренко Н.А. Изучение иммунотропного эффекта препарата ликопид в комплексном лечении воспалительных заболеваний пародонта. Международный журнал прикладных и фундаментальных исследований. 2015;3:639-642]. URL: https://applied-research.ru/ru/article/view?id=6685
- van der Waal I. Symptoms of burning mouth disease. Burning Mouth Disease. 2022:7-14. doi: 10.1007/978-3-030-94226-7_2
- Negre-Barber A, Montiel-Company JM, Boronat-Catalá M, et al. Hypomineralized second primary molars as predictor of molar incisor hypomineralization. Scientific Reports. 2016;6(1):31929. doi: 10.1038/srep31929
Supplementary files
