评估生活在大型工业化地区的超重和肥胖少女的生殖健康状况
- 作者: Antipov M.S.1,2, Zharkin N.A.3,2, Barinova I.A.2, Sherbakova S.V.2, Temirova D.B.2
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隶属关系:
- Moscow Regional Research and Clinical Institute n.a. M.F. Vladimirsky
- Balashikha Regional Hospital
- Volgograd State Medical University
- 期: 卷 11, 编号 2 (2024)
- 页面: 203-212
- 栏目: Original study articles
- URL: https://ogarev-online.ru/2313-8726/article/view/260561
- DOI: https://doi.org/10.17816/aog623723
- ID: 260561
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详细
目标。评估生活在高技术负荷条件下的超重和肥胖少女生殖健康的特点。
材料与方法。对105名15-17岁的少女进行了一次性调查。主要组由70名超重和肥胖的女孩组成,分为两个亚组:有月经不调(N1=42)和无月经不调(N2=28)。对照组包括35名体重正常且无月经失调的女孩。我们研究了发病率,测定了体重指数(BMI)、垂体激素(TTH, FSH, LH)和性激素(雌二醇、DEA-SO4, AMH、睾酮)水平。此外,还测定了谷丙转氨酶、谷草转氨酶、总胆固醇、甲状腺和腹部超声波。对坚持治疗和改变生活方式的情况进行了定量评估分析。
结果。主要组的平均体重指数为31.1 (4.9)千克/平方米,对照组为20.0 (1.9)千克/平方米(p <0.001)。据统计,主要组的女孩心血管疾病发病率较高 (χ2=2.58, p=0.014; OR=5.7; 95% CI, 1.2–26.2),泌尿系统疾病、神经系统和内分泌疾病的发病率也较高。主要组中有22名(31.4%)女孩出现了肝脏和胰腺病变的超声征象,31名(44.0%)女孩出现了甲状腺弥漫性变化,并伴有囊肿形成或发育不良。所有青少年的前卵泡数量均正常。主要组和对照组的青少年在促甲状腺激素(p <0.001), 促黄体激素(p=0.015)和硫酸去氢表雄酮(p=0.002)方面的差异具有统计学意义。15岁青少年对治疗的依从性更明显(χ2=13.28; p=0.003)。
结论。生活在高人为负荷下的超重和肥胖少女,在临床、实验室数据和坚持治疗方面存在差异,因此有必要对可能的发病原因进行更深入的研究,并改进健康改善计划。
作者简介
Mikhail S. Antipov
Moscow Regional Research and Clinical Institute n.a. M.F. Vladimirsky; Balashikha Regional Hospital
Email: info@balob.ru
ORCID iD: 0000-0003-2621-9417
MD, Cand. Sci. (Medicine), Associate Professor
俄罗斯联邦, Moscow; Moscow regionNikolay A. Zharkin
Volgograd State Medical University; Balashikha Regional Hospital
编辑信件的主要联系方式.
Email: zharkin55@mail.ru
ORCID iD: 0000-0002-8094-0427
SPIN 代码: 6309-0515
Scopus 作者 ID: 6602293084
MD, Dr. Sci. (Medicine), Professor
俄罗斯联邦, Volgograd; Moscow regionIrina A. Barinova
Balashikha Regional Hospital
Email: barinova.vsmu@gmail.com
ORCID iD: 0000-0001-5384-5208
MD, obstetrician-gynecologist
俄罗斯联邦, Moscow regionSvetlana V. Sherbakova
Balashikha Regional Hospital
Email: info@balob.ru
ORCID iD: 0009-0004-5640-6306
MD, Deputy Chief Physician for Childhood and Obstetrics
俄罗斯联邦, Moscow regionDiana B. Temirova
Balashikha Regional Hospital
Email: info@balob.ru
ORCID iD: 0009-0009-4681-6893
MD, Head of the Pediatric Department
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