电邮这篇文章 Mitochondrial diseases: causes and solutions (literature review)
- 作者: Ivanova E.D.1, Belousova V.S.1, Skorobogatova O.V.1, Bogomazova I.M.1, Timokhina E.V.1, Pesegova S.V.1
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隶属关系:
- I.M. Sechenov First Moscow State Medical University
- 期: 卷 10, 编号 4 (2023)
- 页面: 243-251
- 栏目: Literature reviews
- URL: https://ogarev-online.ru/2313-8726/article/view/219510
- DOI: https://doi.org/10.17816/2313-8726-2023-10-4-243-251
- ID: 219510
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详细
The discovery of mitochondrial desoxyribonucleic acid (DNA) mutations and the association of these mutations with the development of severe, sometimes, fatal diseases led to new forms of reproductive technologies, i.e., mitochondrial replacement therapy. Currently, researchers are investigating three main methods of mitochondrial replacement therapy: pronuclear transfer, maternal spindle transfer, and polar body genome transfer. Thanks to these methods, the transmission of faulty mitochondrial DNA from the mother to the next generation can be prevented, with the main goal of developing a healthy offspring free of genetic disorders and lethal mitochondrial diseases. However, the implementation of these technologies has raised several moral, social, and cultural concerns, as it marks the emergence of a child with genetic material from three parents for the first time. This review presents an objective summary of the causes of mitochondrial disorders and various techniques employed in mitochondrial replacement therapy, along with their outcomes.
作者简介
Ekaterina Ivanova
I.M. Sechenov First Moscow State Medical University
Email: katerina.dip.13@gmail.ru
ORCID iD: 0009-0006-0016-4701
Student
俄罗斯联邦, MoscowVera Belousova
I.M. Sechenov First Moscow State Medical University
编辑信件的主要联系方式.
Email: belousova_v_s@staff.sechenov.ru
ORCID iD: 0000-0001-8332-7073
MD, Dr. Sci. (Med.), Assistant Professor, Professor of the Department of Obstetrics, Gynecology and Perinatology
俄罗斯联邦, MoscowOksana Skorobogatova
I.M. Sechenov First Moscow State Medical University
Email: aisha27_sum@mail.ru
ORCID iD: 0009-0009-8664-3536
Graduate Student
俄罗斯联邦, MoscowIrina Bogomazova
I.M. Sechenov First Moscow State Medical University
Email: bogomazova_i_m@staff.sechenov.ru
ORCID iD: 0000-0003-1156-7726
MD, Cand. Sci. (Med.), Assistant Professor
俄罗斯联邦, MoscowElena Timokhina
I.M. Sechenov First Moscow State Medical University
Email: timokhina_i_m@staff.sechenov.ru
ORCID iD: 0000-0001-6628-0023
MD, Dr. Sci. (Med.), Assistant Professor, Professor of the Department
俄罗斯联邦, MoscowSvetlana Pesegova
I.M. Sechenov First Moscow State Medical University
Email: pesegova_s_v@staff.sechenov.ru
ORCID iD: 0000-0002-1339-5422
MD, Cand. Sci. (Med.), Assistant Lecturer
俄罗斯联邦, Moscow参考
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