PODOCYTURIA AS A MARKER FOR PREECLAMPSIA


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Abstract

The role of kidneys in the pathogenesis of preeclampsia is still a matter of debate. There is strong evidence that a disturbance in the function of normal kidney due to the loss of podocytes is the main cause of the development of proteinuria and hypertension. The release of podocytes, podocytic proteins and podocytic matrix ribonucleic acid (mRNA) can both be used for the diagnostics of preeclampsia and serve as a marker of the active disease of the kidney. The performed in this review analysis of publications showed that podocytes and podocytic proteins can be detected long before the appearance of proteinuria and hypertension, which makes them promising markers for the early diagnosis of preeclampsia. Measurement of the concentration of nephrin and its mRNA allows both assess the risk of development of preeclampsia and make the differential diagnosis between preeclampsia and gestational hypertension with a sufficiently high efficiency already in the second trimester of pregnancy, long before the appearance of the main signs of the disease.

About the authors

Andrey V. Murashko

I.M. Sechenov First Moscow State Medical University

Email: murashkoa@mail.ru
MD, PhD, DSci., professor, Department of Obstetrics and Gynecology of the I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation Moscow, 119991, Russian Federation

L. Z Faizullin

V.I. Kulakov Scientific center of obstetrics, gynecology and Perinatology

Moscow, 117198, Russian Federation

A. A Murashko

I.M. Sechenov First Moscow State Medical University

Moscow, 119991, Russian Federation

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