ROL' BIOKhIMIChESKIKh MARKEROV V PROGNOZIROVANII PORAZhENIYa TsNS NOVOROZhDENNYKh PRI PREZhDEVREMENNYKh RODAKh

The main goal of a prospective study of 84 pregnant women and children who were born at 22-36 weeks gestational age was estimation predictively adverse criteria of cerebral pathology in premature babies. For the evaluation offetal and newborn’s state we performed cerebral vessels ultrasound dopplerography, neurosonography and determine the level of CNS injury biomarkers in cord blood. The study findings suggest the interaction between perinatal outcomes and initial circulation failure of the fetal CNS blood flow in 97% of cases. The concentration of CNS injury biomarkers (S-100 protein, neuro-specific enolase, antibodies to nerve growth factor, myelin basic protein) should be considered as prognostic criteria to determine a degree ofpreterm babies’ CNS affliction.