Genetic factors for development thrombophilia in pregnant

Abstract

The results of studying the frequency of genetic polymorphism of receptor subunits platelet GP IIb/IIIa in 408 pregnant women.
It was found that in women with thrombophilia normal variant of the gene occurred in 63.6%, heterozygous mutation - in 21%, homozygous mutation - in 15,2% of cases. In healthy women heterozygous mutation was revealed in 15,7%, normal genotype - in 84,3% and homozygous mutations was not detected at all. The connection between the occurrence of clinical manifestations of thrombophilia and the presence of hetero- and homozygous mutations of the subunits of platelet receptor GP IIb/IIIa was shown.