Role of sphingosine in inducted mechanisms of apoptosis of experimental acute renal tubular injury

Abstract

Develop of apoptosis is a specific program. The sphingomielyne metabolites as ceramide and sphingosine, play an important role in programmed cell death.
It is known, that sphingosine is initiate as proliferation and apoptosis.
The purpose of this work is studies the roles of sphingosine in apoptosis activation due to acute renal tubular injury.
Our experimental data confirm supposition of existence sphingomielyne metabolitic way in activation of apoptosis. We are receive the date with contrary maintenance dynamics sphingomielyne and sphingosine in the kidney cells.