Effect of adenylate cyclases activator on the cytoskeleton reorganization in thrombin-induced endothelial barrier dysfunction

I B Alieva; Алиева И Б; I Z Eremina; Еремина И З; O B Savrova; Саврова О Б; A D Verin; Верин А Д

Effect of adenylate cyclases activator on the cytoskeleton reorganization in thrombin-induced endothelial barrier dysfunction

Authors: Alieva IB¹, Eremina IZ², Savrova OB³, Verin AD⁴
Affiliations:
1. Moscow State University
2. People's Friendship University of Russia
3. People's Friendship University of RussiaMiklukho-Maklaya str., 8, Moscow, Russia, 117198
4. Vascular Biology Center, Medical College of Georgia
Issue: No 3 (2011)
Pages: 21-25
Section: Articles
URL: https://ogarev-online.ru/2313-0245/article/view/337281
ID: 337281

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Abstract

This work executed on a model of endothelial monolayer in vitro, is devoted to the study of mechanisms leading to endothelial barrier dysfunction. The dysfunction inductor, thrombin, acts on endothelial cells through a specific receptor, triggering cascades of intracellular reactions (including cytoskeletal reorganization) resulting to increased of endothelial permeability. Thrombin-receptor interaction leads to dissociation of heterotrimeric G-protein subunits (Gi, Gq and G12/13), each of which is potentially capable to handle one or more possible ways of dysfunction development. In the present study we analyzed the role of Gi protein in the occurrence of cytoskeletal disturbances that lead to barrier dysfunction. According to our results, it can be assumed that the activity of Gi protein does not directly affect on the endothelial barrier properties.

Keywords

pulmonary endothelium, endothelial barrier function, endothelial barrier dysfunction, thrombin, actin filaments, microtubules

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Effect of adenylate cyclases activator on the cytoskeleton reorganization in thrombin-induced endothelial barrier dysfunction

Full Text

Abstract

Keywords

About the authors

I B Alieva

I Z Eremina

O B Savrova

A D Verin

Supplementary files