Hyperhomocysteinemia and its correction in posttrombotic syndrome of the lower limbs

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Abstract

The article is about hyperhomocysteinemia which retards recanalization processes after deep vein thrombosis and leads to the lower extremities post-thrombotic syndrome. Levels of blood homocysteine were determined at admission, after 1 and 3 months after the acute thrombosis of the deep veins of the lower extremities. Increased levels of homocysteine were revealed. Maximum concentration of homocysteine was 31.6 mmol/l, which corresponds to moderate hyperhomocysteinemia. In patients receiving anticoagulants for 3 months the level of homocysteine slightly decreased. Prescription of vitamins B6, B9, B12 allows significantly decrease the homocysteine levels, improve health outcomes, reduce the number of patients with class C3-4.

About the authors

R E Kalinin

Ryazan’ State medical University n.a. Acad. I.P. Pavlov

Email: kalinin-re@yandex.ru
Department of angiology, vascular, operative surgery and topographic anatomy

I A Suchkov

Ryazan’ State medical University n.a. Acad. I.P. Pavlov

Email: suchkov_med@mail.ru
Department of angiology, vascular, operative surgery and topographic anatomy

I N Rudakova

Ryazan’ State medical University n.a. Acad. I.P. Pavlov

Email: rudila@mail.ru
Department of angiology, vascular, operative surgery and topographic anatomy

L V Nikiforova

Ryazan’ State medical University n.a. Acad. I.P. Pavlov

Email: rzgmu@rzgmu.ru
Department of angiology, vascular, operative surgery and topographic anatomy

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