Hemodynamics and Tissue Temperature in Bone Union Area of Long Bones Primary Fractures and Refractures: in vivo Experiment
- Authors: Kosimov A.A.1,2, Khodzhanov I.Y.1, Kononovich N.A.3
-
Affiliations:
- Republican Specialized Scientific and Practical Medical Center of Traumatology and Orthopaedics
- Tashkent Medical Academy
- National Ilizarov Medical Research Centre for Traumatology and Ortopaedic
- Issue: Vol 28, No 4 (2022)
- Pages: 159-169
- Section: Theoretical and experimental studies
- URL: https://ogarev-online.ru/2311-2905/article/view/124823
- DOI: https://doi.org/10.17816/2311-2905-1976
- ID: 124823
Cite item
Abstract
Background. Adequate blood flow in tissues during bone union is a factor that enables to achieve positive treatment results.
Aim of study — to study in vivo experiment the features of temperature response and blood flow in consolidation area of tibial primary fractures and refractures.
Methods. A tibial fracture was simulated in rats and then immobilized with external fixator. In series 1 (n = 13) the fixation was kept until union. In series 2 (n = 18) a refracture was simulated 21 days after the surgery and refixed until union. The blood flow and tissue temperature were studied in the fracture area in normal conditions; 21 and 35 days after fracture or refracture; 28 days after the end of fixation.
Results. The temperature and blood flow were of the same type, but of different intensity. Three types of reactions were identified: 1) reduced blood flow velocity and tissue temperature, signs of venous outflow difficulty; 2) increased blood flow, unchanged venous outflow, reduced tissue temperature; 3) slight blood flow decrease, increased venous outflow, slight tissue temperature increase. By the end of fixation (35 days) all parameters in series 1 returned to normal. 28 days after the end of fixation the tissue temperature and venous outflow returned to normal in series 2 animals with the first and the second types of hemodynamics, their blood flow velocity decreased. As for the third type, the tissue temperature returned to normal, the venous outflow and the blood flow velocity increased.
Conclusion. In case of primary fractures, the blood flow and the tissue temperature normalized by the end of fixation. In case of refractures the changes persisted 1 month after the end of fixation.
Keywords
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##article.viewOnOriginalSite##About the authors
Azam A. Kosimov
Republican Specialized Scientific and Practical Medical Center of Traumatology and Orthopaedics; Tashkent Medical Academy
Email: azamrefracture@mail.ru
ORCID iD: 0000-0001-9253-2597
Scopus Author ID: 57212646460
Cand. Sci. (Med.)
Uzbekistan, Tashkent; TashkentIskandar Yu. Khodzhanov
Republican Specialized Scientific and Practical Medical Center of Traumatology and Orthopaedics
Email: prof.Khodjanov@mail.ru
ORCID iD: 0000-0001-9420-3623
Scopus Author ID: 57212658193
Dr. Sci. (Med.), Professor
Uzbekistan, TashkentNatalia A. Kononovich
National Ilizarov Medical Research Centre for Traumatology and Ortopaedic
Author for correspondence.
Email: n.a.kononovich@mail.ru
ORCID iD: 0000-0002-5990-8908
SPIN-code: 4698-3378
Scopus Author ID: 55761916600
ResearcherId: Q-8604-2016
Cand. Sci. (Vet.)
Russian Federation, KurganReferences
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