Vol 2, No 2 (2014)
- Year: 2014
- Articles: 9
- URL: https://ogarev-online.ru/2307-9266/issue/view/5605
Articles
3-5
6-9
RESEARCH OF THE PREPARATION «AMINALON-FARMAK» ON THE PHARMACEUTICAL MARKET OF THE UKRAINE: INFORMATION REVIEW
Abstract
Among the contemporary medicinal remedies the derivatives of g - aminobutyric acid have a special place. The present work is devoted to the remedy «Aminalon» which has a dignity of a combination of nootropic and neuroprotective actions and it has special value for the geriatric and pediatric practices. The task of the authors was a holding of a market review with the purpose to generalize the information about the place of the given remedy as a segment of the pharmaceutical market.
Pharmacy & Pharmacology. 2014;2(2):10-18
10-18
19-22
SESQUITERPENE LACTONES OF LEAVES AND FRUITS OF LAURUS NOBILIS L
Abstract
Bay laurel (Laurus nobilis L.) is common in the Mediterranean region, Europe and America. Widely cultivated in the countries of the Arabian Peninsula and North Africa. As the basic active substances in plants: essential oil components, sesquiterpene lactones, alkaloids, and phenolic compounds (flavonoids, phenolic acids and lignans) are described. In the plant more than 30 sesquiterpene lactones are found. Structural types of these compounds include eudesmanolides, germacranolides, guaianolides. Sesquiterpene lactones isolated from the leaves and fruits of Laurus nobilis, possess antibacterial, antifungal, anti-diabetic, anti-inflammatory, hepatoprotective, neuroprotective and cytotoxic activity. They inhibit the absorption of alcohol increases the activity of hepatic glutathione-S-transferase. Most of these types of activity of sesquiterpene lactones from laurel due to the presence within their structure of α-methylene-g-butyrolactone part. Thus, sesquiterpene lactones-containing leaves and fruits Laurus nobilis could have been an important source of raw materials for the creation of new medicines.
Pharmacy & Pharmacology. 2014;2(2):23-33
23-33
POLYACETYLENE COMPOUNDS IN SPECIES OF GENUS BIDENS
Abstract
In genus Bidens, as well as in family Asteraceae as a whole, different researchers had described polyacetylenes, sesquiterpene lactones and flavonoids. Interest to these classes of substances also has been caused by their antiparasitic, antifungal, antioxidant, cytotoxic and other properties. Within family Asteraceae polyacetylenes are widespread in tribe Heliantheae and genus Bidens . They are capable to be accumulated in all parts of plants of this genus though they have been most often found out in roots. In species of genus Bidens the most widespread are С 17-, С 14-, С 13-polyacetylenes, and also aromatic derivatives and thiophenes. Other group of the polyacetylenes found out in species of the genus - polyacetylene glucosides. According to the majority of researchers of this group of polyacetylenes, the glycosidation is a way facilitating of transportation of typically lipophilic compounds. The majority of these polyacetylenes is revealed in species of genus Bidens.
Pharmacy & Pharmacology. 2014;2(2):34-65
34-65
STUDY OF COORDINATION OF IMMUNOACTIVE PEPTIDES WITH METAL IONS AS A BASIS FOR THE DEVELOPMENT OF INNOVATIVE DRUGS
Abstract
The results of development of the immunomodulator timotsin based on coordination compounds dipeptide isoleucyl-tryptophan with zinc, including the synthesis of low molecular weight peptides by immunoactive activated esters, determination regarding the immunostimulatory activity of thymosin α1, study of coordination of dipeptide isoleucyl-tryptophan with zinc, study the immunostimulatory activity of coordination compounds, the results of preclinical and clinical studies of timotsin. pH-metric method and red-ox titration showed that the interaction of zinc and of dipeptide isoleucyl-tryptophan formed in solution following complex forms: [ZnHL] (lgæ = 3,71), Zn(HL) 2 (lgβ = 0,279), ZnL(HL) (lgβ = 6,6), Zn 2(HL) 2 (lgβ = 188), Zn(OH)(HL) (lgβ = -0,256). It was shown that the immunostimulatory activity of coordination compounds is in 2-8 times greater than the starting dipeptide. The developed immunomodulatory drug timotsin showed high therapeutic efficacy in the treatment of viral hepatitis, malignant tumors of different localization, psoriasis and neurodermatitis. Timotsin is registered in Tajikistan (registration number of medical drug №000085T), Kyrgyzstan (medical drug №7137) and Turkmenistan (registration number 006371).
Pharmacy & Pharmacology. 2014;2(2):66-75
66-75
ANTIBACTERIAL ACTIVITY OF BENZIMIDAZOLES 2-THIO, 2-AMINODERIVATIVES AND COMPLEXES OF BENZIMIDAZOLES WITH TRANSITIONAL METALS
Abstract
The literature data about antibacterial properties of benzimidazole 2-thio-, 2-aminoderivatives and benzimidazole complexes have been generalized and systematized in the review. Today prevention and treatment of diseases caused by microorganisms is an actual problem of modern therapy. Therefore, the search for active molecules, the based on them development of some new, more effective antimicrobial agents is an important task of modern pharmaceutical chemistry. Promising compounds for solving these problems are benzimidazole derivatives. They are available, functionally capable, stable and have a wide spectrum of biological activities (antiviral, anthelmintic, antibacterial, anticancer, antidiabetic). The purpose of this paper is to generalize and systematize information about the antimicrobial action of 2-thio-, 2-amino-substituted benzimidazoles and benzimidazole derivatives complexes with transition metals. These compounds and their complexes with transition metals are active against pathogenic strains Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhimurium, Proteus vulgaris, Bacillus cereus, Micrococcus luteus , Helicobacter рylori and others.
Pharmacy & Pharmacology. 2014;2(2):76-87
76-87
DEVELOPMENT OF A NEW IMMUNOMODULATING DRUG TIMOFER
Abstract
Results of the development of an immunomodulating drug timofer based on coordination compounds isoleucyl-tryptophan dipeptide with iron (II), including the study of coordinate isoleucyl-tryptophan dipeptide with iron (II), the study of the immunostimulatory activity of the coordination compounds, the results of the preclinical and clinical studies of timotsin are presented. Method of pH titration showed that the interaction of zinc and dipeptide isoleucyl-tryptophan formed in solution following complex forms: [Fe (HL ±)] 2+ (β = 1,00×10 34), [Fe (HL ±) 2] 2+ (β = 6,25×10 11), [Fe (HL ±)OH] + (β = 4,01×10 26), [Fe (L -)] + (β = 8,10×10 18), [Fe (L -) 2] + (β = 7,50×10 28), [Fe (L -)OH] + (β = 1,03×10 29). It was shown that the immunostimulatory activity of the coordination compounds is 2 times higher than that starting dipeptide. The substance sample and standard formulation of timofer were developed and standardized. The developed immunomodulatory drug timofer showed a high therapeutic efficacy in the treatment of iron deficiency anemia patients with inflammatory processes and traumatic injuries of the maxillofacial region, with chronic inflammatory diseases of the the genitals (CMV, HSV, chlamydia, chronic endometritis, chronic salpingoopharitis, ureaplasmosis) with chronic bronchitis, chronic obstructive bronchitis, bronchial asthma, pneumonia, chronic glomerulonephritis, and chronic renal failure complicated by anemia Bright, withrheumatic diseases, gynecological patients with anemia of moderate and severe degrees of severity, at surgical treatment of patients with suppurative lung disease, heart disease and chronic pericarditis operated with cardiopulmonary bypass. Timofer is registered in Tajikistan (registration number of medical drug №002866).
Pharmacy & Pharmacology. 2014;2(2):88-97
88-97