BIOPHARMACEUTICAL RESEARCHES IN VITRO ON THE CHOICE OF OPTIMAL COMPOSITION OF PHARMACEUTICAL AID FOR OINTMENT PRODUCTION BASED ON СО 2 EXTRACT OF SCHISANDRA CHINENSIS SEEDS

Schisandra chinensis is valuable species of herbal medicines raw materials (fruits, seeds, caruncles, leaves, stem cortex, and roots with root systems) which are used for medicines and biologically active supplements production in food and cosmetic industry. However nowadays medicines from Schisandra chinensis are only represented by tincture for internal use on domestic pharmaceutical market. There are data about positive implementation of medicines based on raw materials of Schisandra chinensis as external medicine forms in folk medicine and in literature. The purpose of this work is the development of soft external medicine form - ointment based on СО 2 extract of Schisandra chinensis seeds. Biopharmaceutical researches in vitro on the choice of optimal ointment composition by the method of dialysis through semi-permeable membrane were conducted for this purpose. Release rate was calculated in relation to base biologically active substances of Schisandra chinensis - lignans (schizandrin and γ-schizandrin) which determine its basic pharmacological value. Based on the results of the research conducted it is possible to conclude that the best ointment bases are hydrophilous “classic” poly ethylene oxide and oleogel based on paraffinic oil and aerosil.

Schisandra chinensis, schizandrin, γ-schizandrin, ointment, ointment bases, biopharmaceutics