Epidemiology and clinical characteristics of metapneumovirus infection in hospitalized children in Novosibirsk in 2019–2024
- Authors: Kurskaya O.G.1, Nokhova A.R.1, Saroyan T.A.1, Solomatina M.V.1, Kazachkova E.A.1, Gutova T.A.1, Anoshina A.V.2, Simkina O.A.3, Sharshov K.A.1, Shestopalov A.M.1
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Affiliations:
- Federal Research Center for Fundamental and Translational Medicine (FRC FTM)
- Children’s City Clinical Hospital No. 6, Novosibirsk
- Children’s City Clinical Hospital No. 3, Novosibirsk
- Issue: Vol 15, No 5 (2025)
- Pages: 965-976
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/2220-7619/article/view/380216
- DOI: https://doi.org/10.15789/2220-7619-EAC-17906
- ID: 380216
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Abstract
Introduction. Metapneumovirus frequently causes respiratory tract infections in children worldwide, with clinical manifestations ranging from mild upper respiratory tract disease to severe bronchiolitis and pneumonia. However, not all countries conduct regular metapneumovirus infection monitoring that complicates its infection trend analysis. The aim of the work was to analyze the etiological pattern of acute respiratory diseases by assessing proportion of metapneumovirus infection, as well as comparatively assess clinical characteristics of the main acute respiratory viral infections in children in Novosibirsk. Materials and methods. Between November 2019 and May 2024, from children aged 0–17 years, admitted with symptoms of acute respiratory diseases there were collected and analyzed 6468 samples for metapneumovirus and other respiratory viruses using real-time polymerase chain reaction. Results. Viral etiology of acute respiratory diseases in hospitalized children was confirmed in 63.0% (4077/6468) of cases. The etiological ARVI pattern differed significantly in various epidemic seasons. Thus, in 2019–2020, influenza virus (27.8%) and respiratory syncytial virus (21.1%) dominated in the etiology of acute respiratory viral infections, while metapneumovirus was detected only in as few as 1.6% of children. In contrast, in 2020–2021, we observed a sharp increase in the detection rate of metapneumovirus (28%) paralleled with the absence of influenza virus and RSV. At the same time, in the following season (2021–2022) we did not detect any cases of metapneumovirus infection. In the following two seasons, the detection rate of metapneumovirus was about 5%: in children aged 3–6 years it was significantly higher than in infants and children aged 7–17 years. Clinical signs of metapneumovirus infection included fever, cough, dyspnoea, hypoxia and were similar to the manifestations of respiratory syncytial virus infection. At the same time, fever above 39°C and malaise were significantly more frequent in patients with influenza. Conclusion. Understanding the epidemiology of specific respiratory infections, compared with global trends, can help to develop targeted prevention and control measures.
About the authors
O. G. Kurskaya
Federal Research Center for Fundamental and Translational Medicine (FRC FTM)
Email: kurskaya_og@mail.ru
ORCID iD: 0000-0002-1931-2026
PhD (Medicine), Head of the Laboratory of Respiratory Viral Infections; Senior Researcher, Laboratory of Molecular Epidemiology and Biodiversity of Viruses
Russian Federation, NovosibirskA. R. Nokhova
Federal Research Center for Fundamental and Translational Medicine (FRC FTM)
Email: alina-nohova@mail.ru
ORCID iD: 0000-0002-7891-5847
Junior Researcher, Laboratory of Respiratory Viral Infections
Russian Federation, NovosibirskTereza A. Saroyan
Federal Research Center for Fundamental and Translational Medicine (FRC FTM)
Author for correspondence.
Email: 111.st.13@rambler.ru
ORCID iD: 0000-0001-8071-5425
SPIN-code: 9462-0024
Scopus Author ID: 58142611500
Junior Researcher, Laboratory of Respiratory Viral Infections
Russian Federation, NovosibirskM. V. Solomatina
Federal Research Center for Fundamental and Translational Medicine (FRC FTM)
Email: mvsolomatina@frcftm.ru
PhD (Medicine), Senior Researcher, Laboratory of Molecular Epidemiology and Biodiversity of Viruses
Russian Federation, NovosibirskE. A. Kazachkova
Federal Research Center for Fundamental and Translational Medicine (FRC FTM)
Email: kazachkova.evgeniya@gmail.com
Junior Researcher
Russian Federation, NovosibirskT. A. Gutova
Federal Research Center for Fundamental and Translational Medicine (FRC FTM)
Email: theshirskiucot@gmail.com
Research Laboratory Assistant, Laboratory of Respiratory Viral Infections
Russian Federation, NovosibirskAnjelika V. Anoshina
Children’s City Clinical Hospital No. 6, Novosibirsk
Email: anzhelika.anoshina2010@yandex.ru
PhD (Medicine), Head of the Department of Infectious Diseases
Russian Federation, NovosibirskOlga A. Simkina
Children’s City Clinical Hospital No. 3, Novosibirsk
Email: olgasimkina83@yandex.ru
epidemiologist GBUZ NSO «DGKB No. 3».
Russian Federation, NovosibirskK. A. Sharshov
Federal Research Center for Fundamental and Translational Medicine (FRC FTM)
Email: sharshov@yandex.ru
ORCID iD: 0000-0002-3946-9872
PhD (Biology), Head of the Laboratory of Molecular Epidemiology and Biodiversity of Viruses
Russian Federation, NovosibirskA. M. Shestopalov
Federal Research Center for Fundamental and Translational Medicine (FRC FTM)
Email: shestopalov2@mail.ru
DSc (Biology), Professor, Director
Russian Federation, NovosibirskReferences
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