Email this article Outcome of art programs for patients with habitable inequality of pregnancy in anamnesis
- Authors: Korotchenko OE1, Gvozdeva AD2, Syrkasheva AG1
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Affiliations:
- V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
- M.V.Lomonosov Moscow State University
- Issue: Vol 19, No 6 (2017)
- Pages: 43-45
- Section: Articles
- URL: https://ogarev-online.ru/2079-5831/article/view/30040
- DOI: https://doi.org/10.26442/2079-5696_19.6.43-45
- ID: 30040
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Abstract
The aim of the study was to assess the effectiveness of auxiliary reproductive technologies (ART) programs in patients with a habitual miscarriage (HM) in an anamnesis. Materials and methods. A prospective cohort study included 200 patients with infertility, 100 of whom had a history of HM (2 or more pregnancy loss before 22 weeks of gestation) - group 1, and 100 patients had tubular peritoneal infertility without loss of pregnancy in the history (group 2 ). Results. Patients with ART programs with a history of HM are characterized by a higher age and, as a consequence, a lower level of AMH, a greater BMI, a higher level of androgens, and poorer embryological indicators (fewer mature oocytes, more oocytes with dysmorphisms, and fewer blastocysts of excellent quality). The frequency of biochemical and clinical pregnancy did not differ in comparison groups. The frequency of spontaneous abortions was observed in 12% in group 1 and in 3% in group 2 (p=0.0156). The incidence of live birth was 17% in group 1 and 24% in group 2 (p=0.2201). Conclusions. The effectiveness of ART programs is lower in patients with habitual miscarriage: the odds of live birth are 1.4 times lower due to the obtaining of a smaller number of blastocysts of excellent quality, and the chances of spontaneous miscarriage are 4.4 times higher than in patients without loss of pregnancy in the anamnesis.
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##article.viewOnOriginalSite##About the authors
O E Korotchenko
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
Email: okorotchenko@mail.ru
аспирант отд-ния вспомогательных технологий в лечении бесплодия 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
A D Gvozdeva
M.V.Lomonosov Moscow State Universityстудентка 6-го курса фак-та фундаментальной медицины 19192, Russian Federation, Moscow, Lomonosovskii pr., d. 31, korp. 5
A G Syrkasheva
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federationканд. мед. наук, ст. науч. сотр. отд-ния вспомогательных технологий в лечении бесплодия 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
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