Email this article Molecular genetic determinants of stress urinary incontinence in women: Prospective comparative study
- Authors: Mikhelson A.A.1, Lugovykh E.V.1, Lazukina M.V.1, Tretyakova T.B.1, Varaksin A.N.2, Konstantinova E.D.2
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Affiliations:
- Ural Research Institute of Maternal and Childhood Protection
- Institute of Industrial Ecology
- Issue: Vol 25, No 3 (2023)
- Pages: 353-359
- Section: ORIGINAL ARTICLE
- URL: https://ogarev-online.ru/2079-5831/article/view/253872
- DOI: https://doi.org/10.26442/20795696.2023.3.202354
- ID: 253872
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Abstract
Aim. To identify the molecular genetic determinants of stress urinary incontinence (UI) in women.
Materials and methods. A comparative study involving 120 women was conducted. Group 1 (main group) included 80 women with UI. Group 2 (comparison group) included 40 women without UI. Statistic data processing was performed using the Excel software package, SPP Statistics 22.0, Statistica for Windows 10 (TIBCO Software Inc., Palo Alto, CA, USA). The mean and standard deviation were reported for quantitative variables with a normal distribution. The statistical hypotheses on the absence of intergroup differences for quantitative variables with normal distribution were verified using Student's test. The absolute and relative values (in percent) were reported for qualitative variables. The chi-square test was used to verify the statistical hypotheses.
Results. Molecular genetic predictors of UI in women are the carriage of polymorphisms of the estrogen receptor gene ESR1:-351_G and the type I collagen gene COL1A1:1546_T. These polymorphisms can be considered as genotypes of "risk" since their carriage is associated with an increased risk of UI.
Conclusion. Genetically determined disorders of the estrogen receptor function and type I collagen synthesis can be one of the essential mechanisms of stress incontinence occurrence. Studying molecular genetic determinants of stress incontinence can provide a deeper understanding of its pathogenetic mechanisms and develop a personalized approach to surgical correction.
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##article.viewOnOriginalSite##About the authors
Anna A. Mikhelson
Ural Research Institute of Maternal and Childhood Protection
Email: ann_tolmik@mail.ru
ORCID iD: 0000-0003-1709-6187
D. Sci. (Med.), Assoc. Prof.
Russian Federation, YekaterinburgEvgenia V. Lugovykh
Ural Research Institute of Maternal and Childhood Protection
Author for correspondence.
Email: usovaev94@gmail.com
ORCID iD: 0000-0003-4687-6764
Graduate Student
Russian Federation, YekaterinburgMaria V. Lazukina
Ural Research Institute of Maternal and Childhood Protection
Email: masha_balueva@mail.ru
ORCID iD: 0000-0002-0525-0856
Cand. Sci. (Med.)
Russian Federation, YekaterinburgTatiana B. Tretyakova
Ural Research Institute of Maternal and Childhood Protection
Email: tbtretyakova@yandex.ru
ORCID iD: 0000-0002-5715-7514
Cand. Sci. (Med.), Assoc. Prof.
Russian Federation, YekaterinburgAnatoly N. Varaksin
Institute of Industrial Ecology
Email: varaksinanatolij2@gmail.com
ORCID iD: 0000-0003-2689-3006
D. Sci. (Phys.-Math.), Prof.
Russian Federation, YekaterinburgEkaterina D. Konstantinova
Institute of Industrial Ecology
Email: konstantinovaekateri@gmail.com
ORCID iD: 0000-0002-2260-744X
Cand. Sci. (Phys.-Math.)
Russian Federation, YekaterinburgReferences
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