Possibilities of quadripolar radiofrequency therapy as a method of rehabilitation after surgery for pelvic organ prolapse
- 作者: Dobrokhotova Y.E.1, Igor I.I.1, Il'ina I.I.1, Kareva E.N.1, Zalesskaya S.A.1, Nagieva T.S.1, Komagorov V.I.1, Grishin A.I.1, Shadrova P.A.1, Azimova A.I.1
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隶属关系:
- Pirogov Russian National Research Medical University
- 期: 卷 23, 编号 6 (2021)
- 页面: 529-535
- 栏目: ORIGINAL ARTICLE
- URL: https://ogarev-online.ru/2079-5831/article/view/89895
- DOI: https://doi.org/10.26442/20795696.2021.6.201308
- ID: 89895
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Background. This article is devoted to a topical topic in gynecology – genital prolapse and methods of preventing recurrence in the postoperative period. Despite the surgery in the field of correction of genital prolapse, up to 13% of patients require repeated surgical treatment of this pathology in the postoperative period.
Aim. At present, a unified algorithm for rehabilitation after operations to eliminate this pathology has not yet been developed. We proposed a technique for using quadripolar radiofrequency therapy in patients operated on for pelvic organ prolapse in the postoperative period in order to improve the rehabilitation period.
Materials and methods. To achieve our goals, histological material was collected from 60 patients with pelvic organ prolapse before and after surgical treatment to assess the strength of collagenogenesis and reparative processes in the connective tissue of the vagina based on changes in the expression of the RNA matrix of collagen types I and III, genes encoding vascular endothelial growth factor VEGF-A, transforming growth factor TGF-B1 and decorin by polymerase chain reaction. The FSFI-19 questionnaire was used to analyze the quality of the patients' sexual life. We also calculated the vagina health index of patients suffering from this disease.
Results. In the course of the study, it was revealed that when using this method, complete re-epithelization of tissues occurs by 90 days after the operation, metabolic and trophic processes in the tissues of the urogenital tract intensify, and an increased degree of patient satisfaction with the quality of sexual life.
Conclusion. All the results obtained confirmed the therapeutic effect of radiofrequency therapy in the postoperative period, which makes it possible to use the technique as a rehabilitation program after surgical treatment for genital prolapse.
作者简介
Yulia Dobrokhotova
Pirogov Russian National Research Medical University
编辑信件的主要联系方式.
Email: pr.dobrohotova@mail.ru
ORCID iD: 0000-0002-7830-2290
D. Sci. (Med.), Prof.
俄罗斯联邦, MoscowIgor Igor
Pirogov Russian National Research Medical University
Email: igrishin.md@gmail.com
ORCID iD: 0000-0002-2689-2751
D. Sci. (Med.)
俄罗斯联邦, MoscowIrina Il'ina
Pirogov Russian National Research Medical University
Email: iliyina@mail.ru
ORCID iD: 0000-0001-8155-8775
D. Sci. (Med.)
俄罗斯联邦, MoscowElena Kareva
Pirogov Russian National Research Medical University
Email: elenakareva@mail.ru
ORCID iD: 0000-0002-9441-3468
D. Sci. (Med.)
俄罗斯联邦, MoscowSofia Zalesskaya
Pirogov Russian National Research Medical University
Email: sofa.zalesskaya@mail.ru
ORCID iD: 0000-0003-2881-0788
Cand. Sci. (Med.)
俄罗斯联邦, MoscowTamara Nagieva
Pirogov Russian National Research Medical University
Email: nagieva.ts@mail.ru
ORCID iD: 0000-0003-3342-9404
Cand. Sci. (Med.)
俄罗斯联邦, MoscowVladimir Komagorov
Pirogov Russian National Research Medical University
Email: v.i.komagorov@gmail.com
ORCID iD: 0000-0003-4510-4244
Graduate Student
俄罗斯联邦, MoscowAleksandr Grishin
Pirogov Russian National Research Medical University
Email: agrishin@mail.ru
obstetrician-gynecologist
俄罗斯联邦, MoscowPolina Shadrova
Pirogov Russian National Research Medical University
Email: Shadrovapolina@hotmail.com
ORCID iD: 0000-0002-3721-1421
Graduate Student
俄罗斯联邦, MoscowAmina Azimova
Pirogov Russian National Research Medical University
Email: aminayous@mail.ru
ORCID iD: 0000-0001-8528-9648
obstetrician-gynecologist
俄罗斯联邦, Moscow参考
- Barber MD, Maher C. Epidemiology and Outcome Assessment of Pelvic Organ Prolapse. Int Urogynecol J. 2013;24(11):1783-90. doi: 10.1007/s00192-013-2169-9
- Pelvic Organ Prolapse: ACOG Practice Bulletin, Number 214. Obstet Gynecol. 2019;25(6):397-408. doi: 10.1097/AOG.0000000000003519
- Maher C, Feiner B, Baessler K, Christmann-Schmid C. Surgery for women with apical vaginal prolapse. Cochrane Database Syst Rev. 2016;10(10):СD012376. doi: 10.1002/14651858.CD012376
- Kastelein AW, Diedrich CM, Jansen C, Zwolsman SE. Validation of noninvasive focal depth measurements to determine epithelial thickness of the vaginal wall. Menopause. 2019;26(10):1160-5. doi: 10.1097/GME.0000000000001369
- Trutnovsky G, Guzman-Rojas R, Martin A, Dietz HP. Pelvic floor dysfunction – does menopause duration matter? Maturitas. 2013;76(2):134-8. doi: 10.1016/j.maturitas.2013.06.012
- Weintraub AY, Glinter H, Marcus-Braun N. Narrative review of the epidemiology, diagnosis and pathophysiology of pelvic organ prolapse. Int Braz J Urol. 2020;46(1):5-14. doi: 10.1590/S1677-5538.IBJU.2018.0581
- Радзинский В.Е., Ханзадян М.Л., Демура Т.А., Коннон Р. Особенности накопления коллагенов I и III типов и эластина в связочном аппарате матки при пролапсах гениталий (иммуногистохимические исследования). Медицинский вестник Юга России. 2014;4:95-100 [Radzinskij VE, Hanzadyan ML, Demura TA, Konnon R. Features of the accumulation of types I and III collagens and elastin in the ligamentous apparatus of the uterus during genital prolapses (immunohistochemical studies). Medical Bulletin of the South of Russia. 2014;4:95-100 (in Russian)].
- Kastelein AW, Diedrich CM, de Waal L, et al. The vaginal microcirculation after prolapse surgery. Neurourol Urodyn. 2020;39(1):331-8. doi: 10.1002/nau.24203
- De Landsheere L, Munaut C, Nusgens B, et al. Histology of the vaginal wall in women with pelvic organ prolapse: a literature review. Int Urogynecol J. 2013;24(12):2011-20. doi: 10.1007/s00192-013-2111-1
- Gong R, Xia Z. Collagen changes in pelvic support tissues in women with pelvic organ prolapse. Eur J Obstet Gynecol Reprod Biol. 2019;234:185-9. doi: 10.1016/j.ejogrb.2019.01.012
- Краснопольская И.В., Попов А.А., Горина Н.В. Экспрессия генов белков метаболизма коллагена в парауретральной соединительной ткани у женщин с недержанием мочи и пролапсом органов малого таза. Российский вестник акушера-гинеколога. 2015;15(6):36-41 [Krasnopolskya IV, Popov AA, Gorina NV. Gene expression of collagen metabolic proteins in the paraurethral connective tissue of women with urinary incontinence and small pelvic organ prolapse. Russian Bulletin of Obstetrician-Gynecologist. 2015;15(6):36-41 (in Russian)].
- De Landsheere L, Munaut C, Nusgens B, et al. Histology of the vaginal wall in women with pelvic organ prolapse: a literature review. Int Urogynecol J. 2013;24(12):2011-20.
- Bentov I, Reed MJ. Anesthesia, microcirculation, and wound repair in aging. Anesthesiology. 2014;120(3):760-72. doi: 10.1097/ALN.0000000000000036
- Казакова С.Н., Аполихина И.А., Тетерина Т.А., Паузина О.А. Современный подход к терапии синдрома релаксированного влагалища. Медицинский оппонент. 2020;2(10):58-64 [Kazakova SN, Apolihina IA, Teterina TA, Pauzina OA. A modern approach to the therapy of the relaxed vagina syndrome. Medical Opponent. 2020;2(10):58-64 (in Russian)].
- Доброхотова Ю.Э., Нагиева Т.С., Карева Е.Н. Фокусированное радиочастотное лечение синдрома релаксированного влагалища в послеродовом периоде. Акушерство, гинекология и репродукция. 2020;14(4):437-48 [Dobrohotova YuE, Nagieva TS, Kareva EN. Focused radiofrequency treatment of the relaxed vagina syndrome in the postpartum period. Obstetrics, Gynecology and Reproduction. 2020;14(4):437-48 (in Russian)].
- Bhattarai A, Staat M. Modelling of Soft Connective Tissues to Investigate Female Pelvic Floor Dysfunctions. Comput Math Methods Med. 2018;2018:9518076. doi: 10.1155/2018/9518076
- Liu C, Wang Y, Li BS, et al. Role of transforming growth factor β 1 in the pathogenesis of pelvic organ prolapse: A potential therapeutic target. Int J Mol Med. 201;40(2):347-56.
- Vetuschi A, Pompili S, Gallone A, et al. Immunolocalization of Advanced Glycation End Products, Mitogen Activated Protein Kinases, and Transforming Growth Factor-β/Smads in Pelvic Organ Prolapse. J Histochem Cytochem. 2018;66(9):673-86.
- Кругликов И. Неоколлагеногенез: физиологический механизм и эффективность процедур. Les nouvelles esthetiques. 2013;5:32-8 [Kruglikov I. Neokollagenogenez: fiziologicheskii mekhanizm i effektivnost' protsedur. Les nouvelles esthetiques. 2013;5:32-8 (in Russian)].
- Wang S, Lü D, Zhang Z. Effects of mechanical stretching on the morphology of extracellular polymers and the mRNA expression of collagens and small leucine-rich repeat proteoglycans in vaginal fibroblasts from women with pelvic organ prolapse. PLoS One. 2018;13(4):e0193456.
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