Contraceptives with folate – new possibilities for prophylaxis of fetal congenital abnormalities


Cite item

Full Text

Abstract

Neural tube defects (NTD) are a group of fetal congenital abnormalities which are formed in the first weeks of embryonal development. NTDs are formed when neural tube is not fully closed for the first 28 days after conception, i.e when a woman does not already know that she is pregnant. It is proven that risk of NTD is reduced with increase of folate concentration in blood. Recently, two new combined oral contraceptives wit folates. The main aim of the development – prophylaxis of fetal congenital abnormalities which is provided with increased level of folates in organism of women of reproductive age when contraceptives are taken and withdrawn, due to contraceptives enriched with folates. Folates which are contained in combined oral contraceptives with folate, reduce NTD risk if a woman gets pregnant while taking the drug or soon after the drug withdrawal.

About the authors

V N Prilepskaya

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава РФ, Москва

д-р мед. наук, проф., зам. дир. по научной работе ФГБУ НЦАГиП им. акад. В.И.Кулакова

E I Ivanova

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава РФ, Москва

аспирант научно-поликлинического отд-ния ФГБУ НЦАГиП им. акад. В.И.Кулакова

L L Bostandjan

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава РФ, Москва

канд. мед. наук, врач научно-поликлинического отд-ния ФГБУ НЦАГиП им. акад. В.И.Кулакова

References

  1. Анализ данных об эффекте КОК на основе доказательной медицины из систематического обзора Кохрановской библиотеки (2008–2011 гг.).
  2. Bart S.S et al. Contraception 2012; 85: 42–50.
  3. Botto L.D et al. N Engl J Med 1999; 341 (20): 1509–19.
  4. Arya R et al. J Neonatol 2006; 20 (4): 316–26.
  5. Cheschier N. Int J Gynaecol Obstet 2003; 83 (1): 123–33.
  6. De Jong-Van den Berg L.T et al. Am J Gynaecol Obstet 2005; 192 (1): 121−8.
  7. USPSTF. Ann Intern Med 2009;150 (9): 626–31.
  8. EUROCAT. http://www.eurocat-network.eu/content/Special-Report-NTD-3rdEd-Part-IIA.pdf
  9. EUROCAT. http://www.eurocat-network.eu/content/Special-Report-NTD-3rdEd-Part-IIB.pdf
  10. Lamers Y et al. Am J Clin Nutr 2006; 84 (1): 156–61.
  11. De-Regil L.M et al. Cochrane Database Syst Rev 2010: CD007950.
  12. MMWR Morb Mortal Wkly Rep 2004; 53 (17): 362–5.
  13. Busby A et al. BMJ 2005; 330 (7491): 574–5.
  14. Food & Drug Administration. http://www.fda.gov/ ohrms/dockets/ac/03/minutes/ 4002M1_Final.pdf
  15. Brown J. Nutrition through the life cycle (Third edition) 2008.
  16. Daly L.E et al. JAMA 1995; 274: 1698–1702.
  17. Von Stenglin A et al. Eur J Contracept Reprod Health Care 2010; 15 (s1): 111–2.
  18. Von Stenglin A et al. Eur J Contracept Reprod Health Care 2010; 15 (s1): 37–8.
  19. Von Stenglin A et al. Eur J Contracept Reprod Health Care 2010; 15 (s1): 112–13.
  20. Cronin M et al. Obstet Gynecol 2009; 114 (3): 616–22.
  21. Diefenbach K et al. Eur Contracept Reprod Health Care 2010; 15 (s1): 111–2.
  22. Thomson Wadsworth: 109–110. Daly L.E et al. JAMA 1995; 274: 1698–702.
  23. Osterhues A et al. Lancet 2009; 374 (9694): 959–61.
  24. Ravin C.R. AWHONN Lifelines 2004; 8 (1): 12–3.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2013 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).