Accelerometry in Diagnosis of Functional Tremor

Konstantin M. Evdokimov; Евдокимов Константин Михайлович; Ekaterina O. Ivanova; Иванова Екатерина Олеговна; Amayak G. Brutyan; Брутян Амаяк Грачевич; Ekaterina Y. Fedotova; Федотова Екатерина Юрьевна; Sergey N. Illarioshkin; Иллариошкин Сергей Николаевич

doi:10.17816/ACEN.1144

Accelerometry in Diagnosis of Functional Tremor

作者: Evdokimov K.M.¹, Ivanova E.O.¹, Brutyan A.G.¹, Fedotova E.Y.¹, Illarioshkin S.N.¹
隶属关系:
1. Research Center of Neurology
期: 卷 18, 编号 4 (2024)
页面: 5-11
栏目: Original articles
URL: https://ogarev-online.ru/2075-5473/article/view/282499
DOI: https://doi.org/10.17816/ACEN.1144
ID: 282499

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Introduction. Functional tremor (FT) is the most common phenotype of functional movement disorders. Electrophysiological assessment is included in the diagnostic criteria for tremor; however, there is currently no consensus criteria for the differential diagnosis of FT.

The objective of this study was to evaluate the utility of tremor frequency characteristics derived from accelerometry for the differential diagnosis between FT and organic tremor (OT).

Materials and methods. Nineteen patients with FT, 20 patients with essential tremor, and 20 patients with Parkinson's disease were enrolled in the study and underwent electrophysiological examination with a two-channel accelerometer and subsequent data processing.

Results. The study results revealed the differences in the frequency peak widths in patients with FT and OT, predominantly while performing a cognitive load task. This criterion showed a high sensitivity (100%) and a high specificity (97.5%) for the diagnosis of FT in the study population.

Conclusion. Tremor characteristics recorded during accelerometry combined with cognitive load task can serve as an additional testing aid for differential diagnosis between functional and organic tremor.

关键词

functional movement disorders, functional tremor, diagnosis, accelerometry

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D. Sci. (Med.), prof., RAS Full Member, Director, Brain Institute, Deputy director

俄罗斯联邦, Moscow

参考

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2. Fig. 1. Tremor frequency peak width was measured with Tremoroton software. Upper and lower limits of the frequency peak of accelerometer oscillations were determined manually at 40–50% from the height of the frequency peak. The peak width is defined as a difference between upper and lower limits. The red thin arrow indicates the point where the dominant frequency of the peak is measured. The red bold arrow and blue bar indicate the points where the peak width was measured. A — the frequency spectrum in a patient with FT; B — in a patient with PD; АСС — accelerometer oscillations; EMG ext — EMG-recordings from wrist extensors; EMG flex — EMG-recordings from wrist flexors.

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3. Fig. 2. Results of a posteriori pairwise comparison between FT, ET, and PD patients. А — PT frequency peak width without CL; CL — cognitive load; PT — postural tremor; B — PT frequency peak width with CL; C — difference in PT frequency peak width without CL; D — shift of minimum frequency peak (lower limit); E — shift of maximum frequency peak (upper limit); F — ratio of the mean amplitude of PT oscillations with CL to the mean amplitude of PT oscillations without CL.

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