Characteristics of Patients with Hereditary Transthyretin Amyloid Polyneuropathy and Chronic Idiopathic Axonal Polyneuropathy in Russia: PRIMER Study Results

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Abstract

Introduction. Hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) is a severe progressive hereditary disease. Even with the availability of genetic testing for transthyretin (TTR) gene variants, timely hATTR-PN diagnosis remains challenging due to a great variability in its clinical presentation. Patients with hATTR-PN are often misdiagnosed with chronic idiopathic axonal polyneuropathy (CIAP).

The objective of our study is to describe the baseline electrophysiological, clinical, and demographic characteristics of hATTR-PN and CIAP patients and to establish patients' pre-selection criteria for genetic testing.

Materials and methods. Retrospective analysis was performed in 42 hATTR-PN patients and 58 CIAP patients (according to diagnosis defined in medical records from 1 January 2017 to 1 March 2024). Demographic, clinical, and electrophysiological data were collected at diagnosis. To identify factors influencing the likelihood of the hATTR-PN presence, a logistic regression model including clinically relevant variables was developed.

Results. The mean age of hATTR-PN and CIAP patients was 57.7 and 60.9 years, respectively. As compared with CIAP patients, those with hATTR-PN more frequently exhibited gait disturbances (64.3% vs 37.9%), autonomic (47.6% vs 12.1%), cardiac (35.7% vs 10.3%) and gastrointestinal symptoms (64.3% vs 12.1%), unintentional weight loss (45.2% vs 12.1%), and heart failure with preserved ejection fraction (26.2% vs 6.9%). Peripheral nerve conduction scores were also lower in the hATTR-PN group. In predicting hATTR-PN, the logistic regression model had a sensitivity of 91% and a specificity of 97%.

Conclusion. Demographic, clinical, and electrophysiological characteristics of patients with hATTR-PN and CIAP were described. Based on the screening data, it is feasible to predict hATTR-PN in CIAP patients with relatively high accuracy, sensitivity, and specificity.

About the authors

Natalya A. Suponeva

Research Center of Neurology

Author for correspondence.
Email: suponeva@neurology.ru
ORCID iD: 0000-0003-3956-6362

Dr. Sci. (Med.), Corresponding Member of RAS, Director of the Institute of Neurorehabilitation and Restorative Technologies

Russian Federation, Moscow

Olga E. Zinovieva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: suponeva@neurology.ru
ORCID iD: 0000-0001-5937-9463

Dr. Sci. (Med.), Professor, Department of nervous system diseases and neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine

Russian Federation, Moscow

Fatima R. Stuchevskaya

Medical Center “Reavita Med SPb”; City Multidisciplinary Hospital No. 2; First Pavlov State Medical University of St. Petersburg

Email: suponeva@neurology.ru
ORCID iD: 0000-0003-3181-4229

Cand. Sci. (Med.), Associate Professor, Neurology department, neurologist, Head, Neurological department No. 3

Russian Federation, Saint Petersburg; Saint Petersburg; Saint Petersburg

Tatyana G. Sakovets

Republican Clinical Hospital; Kazan State Medical University

Email: suponeva@neurology.ru
ORCID iD: 0000-0002-0713-9836

Cand. Sci. (Med.), Associate Professor, Neurology and rehabilitation department, neurologist

Russian Federation, Kazan; Kazan

Darya A. Grishina

Research Center of Neurology

Email: suponeva@neurology.ru
ORCID iD: 0000-0002-7924-3405

Cand. Sci. (Med.), Head, Center for Peripheral Nervous System Diseases, Institute of Clinical and Preventive Neurology

Russian Federation, Moscow

Maria S. Kazieva

Research Center of Neurology

Email: suponeva@neurology.ru
ORCID iD: 0009-0007-5683-0934

neurologist

Russian Federation, Moscow

Elvira I. Safiulina

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: suponeva@neurology.ru
ORCID iD: 0000-0002-1233-7626

Cand. Sci. (Med.), neurologist

Russian Federation, Moscow

Anton P. Soloviev

AstraZeneca Pharmaceuticals LLC

Email: suponeva@neurology.ru
ORCID iD: 0009-0001-3407-7220

medical advisor

Russian Federation, Moscow

Evgenia A. Zorina

AstraZeneca Pharmaceuticals LLC

Email: suponeva@neurology.ru
ORCID iD: 0009-0004-9283-5714

Head, Therapeutic direction

Russian Federation, Moscow

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Copyright (c) 2024 Suponeva N.A., Zinovieva O.E., Stuchevskaya F.R., Sakovets T.G., Grishina D.A., Kazieva M.S., Safiulina E.I., Soloviev A.P., Zorina E.A.

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