The results of the 10-year experience of a Regional Center of care for patients with parkinsonism and extrapyramidal pathology in Yaroslavl and Yaroslavl region
- Authors: Kurapin E.V.1, Bykanova M.A.2, Trofimova N.V.3
-
Affiliations:
- Yaroslavl Regional Clinical Hospital
- Yaroslavl State Medical University
- Pereslavl Central Regional Hospital
- Issue: Vol 12, No 2 (2018)
- Pages: 12-21
- Section: Original articles
- URL: https://ogarev-online.ru/2075-5473/article/view/124283
- DOI: https://doi.org/10.18454/ACEN.2018.2.2
- ID: 124283
Cite item
Full Text
Abstract
Introduction. In 2007, a consultation center for patients with parkinsonism (a Regional Center) was organized in the city of Yaroslavl and Yaroslavl region. It was one of the first centers of parkinsonism over Russia.
Objective. To study and compare the clinical and epidemiological features of parkinsonism in Yaroslavl and the Yaroslavl region in different periods of work of the Regional Center.
Materials and methods. A total number of 6,272 patients were examined in the Regional Center in 2007–2017.
Results. Parkinson disease (PD) was ranked first (over 80%) in the structure of parkinsonism during the whole time of activity of the Regional Center. The incidence of the syndrome of vascular parkinsonism was significantly lower in 2012–2017, and the dementia with Lewy bodies was significantly higher compared to 2007–2012. Prevalence of PD in the year of 2017 in Yaroslavl amounted to 138.14 per 100,000 population, and across Yaroslavl region until 2017 year – 127.01 per 100,000 population. PD patients from towns of Yaroslavl region (82.9%) significantly prevailed in comparison with rural patients (17.1%). In 2012–2017, PD was diagnosed at the first stage twice as often as in the period of 2007–2012. In 2012–2017, the preliminary diagnosis matched a refined diagnosis of PD in 84% of cases.
Conclusion. During recent 5 years of the activity of the Regional Center the town neurologists of Yaroslavl region identified a great number of new patients with extrapyramidal disorders. Since then significantly fewer errors has being made by the neurologists in the preliminary diagnoses and more PD has been detected at earlier stages.
About the authors
Eugeny V. Kurapin
Yaroslavl Regional Clinical Hospital
Email: privase@mail.ru
Russian Federation, Yaroslavl
Maria A. Bykanova
Yaroslavl State Medical University
Author for correspondence.
Email: privase@mail.ru
Russian Federation, Yaroslavl
Natalya V. Trofimova
Pereslavl Central Regional Hospital
Email: privase@mail.ru
Russian Federation, Pereslavl
References
- Illarioshkin S.N. Parkinson's disease and the problem of generics. Nervnye bolezni 2015; (1): 2–5. (in Russ.).
- Seliverstov Yu.A., Illarioshkin S.N. Prevalence and main methods of treatment of advanced stages of Parkinson’s disease. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2013; 11: 100–106. (in Russ.).
- Razdorskaya V.V., Voskresenskaya O.N., Yudina G.K. Parkinson disease in Russia: prevalence and incidence (review). Saratov Journal of Medical Scientific Research 2016; 12(3): 379–384. (in Russ.).
- Kurapin E.V., Baranova N.S. Parkinsonism (etiology, clinic, diagnosis, treatment). Yaroslavl': Remder, 2016. (in Russ.).
- Levin O.S. How to treat Parkinson's disease in 2013. Sovremennaya terapiya v psihiatrii i nevrologii 2013: (3): 5–16. (in Russ.).
- American Parkinson Disease Association. Early onset Parkinson’s disease. https://www.apdaparkinson.org/what-is-parkinsons/early-onset-parkinsons-disease (13.06.2016).
- Krivonos O.V. Medico-social aspects of extrapyramidal diseases – a look at the problem. The Neurological Journal 2010; 15(6): 47–49. (in Russ.).
- Zhuchenko T.D., Vein A.M., Golubev V.L. et al. Vascular Parkinsonism. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 1998; 98(4): 62–65. (in Russ.).
- Levin O.S. Clinical-neuropsychological and neuroimaging aspects of differential diagnosis of Parkinsonism. Diss. … dokt. med. nauk. Moscow, 2003. (in Russ.).
- Pizova N.V., Bykanova M.A., Kurapin E.V. et al. Parkinsonism in in the Yaroslavl region: clinico-epidemiological aspects and a working experience of a specialized center. Annals of Clinical and Experimental Neurology 2011; 5(2): 18–23.
- Levin O.S., Dokadina L.V. Epidemiologiya parkinsonizma i bolezni Parkinsona. The Neurological Journal 2005; 10(5): 41–49. (In Russ.).
- Razdorskaya V.V., Iudina G.K., Voskresenskaia O.N. Statistics of outpatient cases of Parkinson's disease Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2012; 112(9): 72–76. PMID: 23235417.
- Zalyalova Z.A., Kalashnikova O.S., Abdulgalimova D.M. Parkinsonism in the Republic of Tatarstan according to the work of the Republican clinical and diagnostic center of extrapyramidal pathology and botulinum therapy. Nevrologicheskiy vestnik. 2011; 43(2): 92–96. (In Russ.).
- Koval'chuk A.Yu., Bykanova M.A., Pizova H.B. et al. Clinical and epidemiological aspects of Parkinson's disease. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2011; 111(12): 74–76. (In Russ.).
- Levin O.S. Diagnosis and treatment of dementia in clinical practice. Moscow: MEDpress-inform; 2010. (In Russ.).
- Zalyalova Z.A. Current classifications of dystonies, treatment strategy. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2013; 113(3): 85–89. (In Russ.).
- Epidemiology study of Dystonia Europe (ESDE) Collaborative Croup. A prevalence study of primary dystonia in eight European countries. J Neurol 2000; 247(10): 787–792. PMID: 11127535.
- Risch N., de Leon D., Ozelius L. et al. Genetic analysis of idiopathic torsion dystonia in Ashkenazi Jews and their recent descent from a small founder population. Nat Genet 1995; 9(2): 152–159. doi: 10.1038/ng0295-152. PMID: 7719342.
- Defazio G. The epidemiology of primary dystonia: current evidence and perspectives. Eur J Neurol 2010; 17 Suppl 1: 9–14. doi: 10.1111/j.1468-1331.2010.03053.x. PMID: 20590802.
- Razdorskaya V.V., Voskresenskaya O.N., Yudina G.K. Diagnostic reliability of the outpatient unit of neurological care for patients with Parkinson's disease. Saratov Journal of Medical Scientific Research 2012; 8(2): 513–517. (In Russ.).
- Sapronova M.R., Shnayder N.A. The epidemiological, clinical, and genetic characteristics of Parkinson's disease (in case of Zheleznogorsk). Neurology, Neuropsychiatry, Psychosomatics 2014; (4): 59–64. (In Russ.).
- Dokadina L.V. Parkinsonizm: Clinical-epidemiological aspects and the state of outpatient care at the regional level. Avtoref. dis. … cand. med. nauk. Moscow; 2004. (In Russ.).
- Obukhova A.V. Modern therapy of Parkinson's disease. Neurology, Neuropsychiatry, Psychosomatics 2014; (3): 80–84. (In Russ.).
Supplementary files
