Comparative evaluation of the therapeutic efficacy and the safety of the Tetraderm® cream in comparison with the Triderm® cream in patients with allergic dermatoses, complicated by secondary infection
- Authors: Kasatkin E.V.1, Givirovskiy S.E.1, Pisarev V.V.2, Merkulov M.E.2, Storozheva K.V.3, Fedotova O.V.4, Doshchuk N.A.4
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Affiliations:
- Dermatovenerologic Dispensary №8
- “Probiotech” LLC
- Saint Petersburg State University
- JSC “WERTEKS”
- Issue: Vol 23, No 8 (2021)
- Pages: 676-681
- Section: Articles
- URL: https://ogarev-online.ru/2075-1753/article/view/97109
- DOI: https://doi.org/10.26442/20751753.2021.8.201087
- ID: 97109
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Abstract
Often allergic dermatoses complicated by a secondary infection. The main causative agents of pustular skin infections are gram-positive cocci. The goals of external therapy are to eliminate the inflammatory reaction and subjective sensations, eliminate secondary bacterial and fungal infections, reduce dry skin and protect against adverse environmental factors. The effectiveness of local therapy is ensured by properly selected dosage forms of drugs. The aim of this study was to conduct a comparative assessment of the therapeutic efficacy and safety of Tetraderm® cream and Triderm® cream in patients with inflammatory dermatoses with concomitant bacterial and mycotic infections. The study involved 128 patients, depending on the drug used, the patients were divided into 2 groups. Efficacy was assessed by the relative number of patients (%) with the achieved therapeutic success (by index EASI), the relative number of patients (%) with the achieved therapeutic success on the scale of total clinical judgment of a physician relative number of patients (%) with the achieved improvement in the change in dermatology life quality index – DLQI, as well as according to the objective methods of investigation. Safety was evaluated on the basis of monitoring and registration of adverse events, data from clinical laboratory tests. Both drugs demonstrated similar therapeutic efficacy and did not differ in any of the efficacy criteria, both in the ITT population and in the PP population, and also proved to be equally safe.
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##article.viewOnOriginalSite##About the authors
Evgenii V. Kasatkin
Dermatovenerologic Dispensary №8
Author for correspondence.
Email: kasatkine@mail.ru
Cand. Sci. (Med.)
Russian Federation, Saint PetersburgStanislav E. Givirovskiy
Dermatovenerologic Dispensary №8
Email: stanislav_givirovskiy@mail.ru
dermatovenerologist
Russian Federation, Saint PetersburgVladimir V. Pisarev
“Probiotech” LLC
Email: vladimir.pisarev@probiotech.ru
ORCID iD: 0000-0003-3212-4369
Cand. Sci. (Chem.)
Russian Federation, MoscowMikhail E. Merkulov
“Probiotech” LLC
Email: mikhail.merkulov@probiotech.ru
ORCID iD: 0000-0002-1987-992X
specialist
Russian Federation, MoscowKseniia V. Storozheva
Saint Petersburg State University
Email: kvstorozheva@mail.ru
Clinical Resident
Russian Federation, Saint PetersburgOlga V. Fedotova
JSC “WERTEKS”
Email: ofedotova@vertex.spb.ru
ORCID iD: 0000-0002-6409-1250
Medical Advisor
Russian Federation, Saint PetersburgNikita A. Doshchuk
JSC “WERTEKS”
Email: ndoshchuk@vertex.spb.ru
ORCID iD: 0000-0003-3351-0229
Medical Advisor
Russian Federation, Saint PetersburgReferences
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