Effectiveness of Theraflex® evaluation in early stages of osteoarthritis treatment and its influence on articular cartilage structure and metabolism
- Authors: Luneva S.N1, Sazonova N.V1, Malceva L.V1, Matveeva E.L1
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Affiliations:
- G.A.Ilizarov Russian Scientific Center of Restorative Traumatology and Orthopedics of the Ministry of Health of the Russian Federation
- Issue: Vol 20, No 9 (2018)
- Pages: 63-70
- Section: Articles
- URL: https://ogarev-online.ru/2075-1753/article/view/95097
- DOI: https://doi.org/10.26442/2075-1753_2018.9.63-70
- ID: 95097
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Abstract
Rationale. The main concern of early stages osteoarthritis treatment is finding pathogenically justified medications. An important role of inflammatory and destruction components in the disease development induces necessity for modern combined cartilage protectors effectiveness study. Objective. To evaluate effectiveness and safety of combined symptomatic medication with delayed effect Theraflex® use in osteoarthrosis treatment according to clinical symptoms, physical examination, and biochemical tests of connective tissue metabolism parameters. Materials and methods. Biochemical values of connective tissue matrix destruction and electrolytes values were evaluated in serum and urine samples of 44 patients (22 patient from group 1 in whom standard treatment combined with Theraflex® was used and 22 patients in whom only standard treatment was used). Also X-ray imaging was performed and functional severity of osteoarthrosis and pain syndrome were evaluated. Results. Effectiveness of Theraflex® use in early stages of osteoarthritis treatment was shown from the perspective of its influence on arthrodial cartilage structure and metabolism. The conducted biochemical studies of serum and 24-hour urine allowed to establish that after Theraflex® use the connective tissue biopolymers metabolism parameters return to normal. The study of clinical and radiological results of Theraflex® use in osteoarthritis patients indicates its positive effect after short term use. Conclusions. The conducted study proved symptom- and structure-modifying drug effect of the medication that was shown in sonographic and radiologic characteristics of articular cartilage and subchondral bone. Improvement of connective tissue metabolism biochemical characteristics allows us to recommend the medication use in early stages osteoarthritis treatment.
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##article.viewOnOriginalSite##About the authors
S. N Luneva
G.A.Ilizarov Russian Scientific Center of Restorative Traumatology and Orthopedics of the Ministry of Health of the Russian Federation
Email: luneva_s@mail.ru
д-р мед. наук, проф., зав. лаб. биохимии 640014, Russian Federation, Kurgan, ul. M.Ulyanovoi, d. 6
N. V Sazonova
G.A.Ilizarov Russian Scientific Center of Restorative Traumatology and Orthopedics of the Ministry of Health of the Russian Federationд-р мед. наук, зав. КДО 640014, Russian Federation, Kurgan, ul. M.Ulyanovoi, d. 6
L. V Malceva
G.A.Ilizarov Russian Scientific Center of Restorative Traumatology and Orthopedics of the Ministry of Health of the Russian Federationврач ультразвуковой диагностики лаб. рентгеновских и ультразвуковых методов диагностики 640014, Russian Federation, Kurgan, ul. M.Ulyanovoi, d. 6
E. L Matveeva
G.A.Ilizarov Russian Scientific Center of Restorative Traumatology and Orthopedics of the Ministry of Health of the Russian Federationд-р биол. наук, вед. науч. сотр. лаб. биохимии 640014, Russian Federation, Kurgan, ul. M.Ulyanovoi, d. 6
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