Effect of nitrendipine on Ca2+-homeostasis of neurons and activity of cytotoxic factors in Alzheimer's disease


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Abstract

The review considers the hypothesis of the "amyloid cascade” and the "calcium" hypothesis in the onset and progression of Alzheimer's disease in the light of recent experimental data. Particular attention is paid to the change in the homeostasis of Ca2+ and Ca2+ ions upon the action of cytotoxic р-amyloid peptides (Ар-peptides) and hyperphosphorylated tau proteins on neurons. Using the example of the dihydropyridine blocker of Ca2+ -channels of nitrendipine, new mechanisms of its protective action are presented, which are associated with a decrease in the formation of Ар-peptides and their removal from the brain into the blood (clearance Ар).

About the authors

E. I Astashkin

I. M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Email: ast-med@mail.ru
119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 1

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