Assessment of the quality of life of pediatric patients with multiple sclerosis

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Abstract

Background. Multiple sclerosis (MS) is a chronic Demyelinating disease, the onset of MS occurs in childhood in 5% of cases. MS has a great impact on the quality of life (QoL) of children, especially during periods of exacerbation of the disease.

Aim. To assess the quality of life of pediatric patients with MS and identification the factors that have impact on it.

Materials and methods. Examined 22 patients with MS in exacerbation and remission (no exacerbations for 6 months) and 20 healthy children, comparable in gender and age. The quality of life of children was assessed using the Pediatric Quality of Life Questionnaire – PedsQL 4.0.

Results. QoL of children have significally decreased during exacerbation of MS compared with remission (p<0.001). The indicators of QoL in remission of MS are not differ from those in healthy controls (p=0.294). QoL in children with MS during the period of exacerbation is lower than in healthy controls (p<0.001). Lower QoL is associated with more disability on the EDSS scale. The duration of the MS and the age of onset do not affect the QoL of patients.

Conclusion. Exacerbations of multiple sclerosis reduce the quality of life of children, and QoL decrease correlates with the severity of neurological deficits. When remission is achieved and maintained, the quality of life is restored and does not differ from that of healthy children.

About the authors

Nailya F. Akhmetgaleeva

Bashkir State Medical University; Republican Children’s Clinical Hospital

Author for correspondence.
Email: nailya_9292@list.ru
ORCID iD: 0000-0003-1409-6704

Graduate Student

Russian Federation, Ufa; Ufa

Taras O. Simaniv

Scientific Center of Neurology

Email: nailya_9292@list.ru
ORCID iD: 0000-0001-7256-2668

Cand. Sci. (Med.)

Russian Federation, Moscow

Klara Z. Bakhtiyarova

Bashkir State Medical University

Email: nailya_9292@list.ru
ORCID iD: 0000-0003-0982-4324

D. Sci. (Med.)

Russian Federation, Ufa

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Supplementary files

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2. Fig. 1. QOL in patients in exacerbation and remission stages.

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3. Fig. 2. Indices of physical functioning in the exacerbation and remission stages.

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4. Fig. 3. QOL of patients with exacerbated MS and healthy adolescents.

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5. Fig. 4. Indices of physical functioning of patients with MS in the exacerbation stage and healthy adolescents.

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6. Fig. 5. Indicators of emotional functioning of patients in the stage of exacerbation and healthy adolescents.

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7. Fig. 6. QOL of patients with MS in remission and healthy adolescents.

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8. Fig. 7. Correlation between the degree of disability in MS exacerbation and CV.

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