Virucidal efficacy of cetylpyridinium chloride and benzydamine hydrochloride fixed combination lozenges against influenza A virus: A review
- Authors: Filippova O.V.1
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Affiliations:
- Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 24, No 9 (2022)
- Pages: 588-594
- Section: Articles
- URL: https://ogarev-online.ru/2075-1753/article/view/120374
- DOI: https://doi.org/10.26442/20751753.2022.9.201857
- ID: 120374
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Abstract
Cetylpyridinium chloride (CPC) is effective against respiratory viruses, including influenza. Septolete® Total, lozenges containing CPC and benzydamine, demonstrated virucidal activity against influenza A virus, higher than CPC alone.
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##article.viewOnOriginalSite##About the authors
Olga V. Filippova
Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: ffiona@mail.ru
ORCID iD: 0000-0001-9470-6335
D. Sci. (Med.)
Russian Federation, MoscowReferences
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Figure 1. Transmission (transmission) electron microscopy (TEM) demonstrates that CPC disrupts the integrity of the viral envelope and the morphology of the influenza virus: a - raw influenza virus; b, c – influenza virus treated with 50 μg/ml CPC for 5 min. The scale is located in the lower left corner at a distance of 100 nm (a) or 50 nm (b, c) [8].
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Figure 2. Release of influenza nucleoproteins from the virus in response to an increase in CPC [8].
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Figure 3. Influenza A virus exposure of the test substance at the highest concentration (equivalent to a solution of 1 lozenge in 4 ml suspension) at three different contact times.
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Figure 4. Comparison of the reduction in infectious viruses at the highest concentration (equivalent to a solution of 1 lozenge in 4 ml suspension) at three different exposure times.
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