Successful achievement of remission in acne conglobata: a clinical case
- Authors: Kucher I.E.1, Kabanov V.N.1, Pravdina O.V.2, Novikov Y.A.1,2, Radul E.V.2
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Affiliations:
- Clinical Dermatovenereology Dispensary
- Omsk State Medical University
- Issue: Vol 32, No 10 (2025)
- Pages: 143-147
- Section: Clinical case
- URL: https://ogarev-online.ru/2073-4034/article/view/380912
- DOI: https://doi.org/10.18565/pharmateca.2025.10.143-147
- ID: 380912
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Abstract
Background: Acne is a common skin condition affecting individuals of both sexes, primarily between the ages of 12 and 25. Acne conglobata is considered the most severe form of acne due to its pronounced inflammatory response, frequent development of persistent cosmetic defects, adverse psychosocial consequences, and resistance to treatment.
Description of the clinical case: Clinical case of acne conglobata (nodularis) in a male patient, born in 2005, with no signs of somatic pathology, is described. Outpatient treatment with isotretinoin was administered for 18 months (cumulative dose of 172 mg/kg body weight). Initially, reduced daily doses of isotretinoin were used in combination with prednisolone and antibacterial agents. This resulted in stable remission. The patient was declared fit for military service without restrictions.
Conclusion: Severe acne can lead to the formation of persistent scarring not only directly but also due to the development of purulent complications requiring surgical intervention. Achieving stable remission may require a more cautious initiation of isotretinoin therapy, as well as an increased treatment duration and effective cumulative dose compared to standard treatments.
About the authors
Irina E. Kucher
Clinical Dermatovenereology Dispensary
Author for correspondence.
Email: diamondkdd@mail.ru
ORCID iD: 0009-0009-3900-3851
Dermatovenereologist, Outpatient Department No. 4
Russian Federation, OmskVladislav N. Kabanov
Clinical Dermatovenereology Dispensary
Email: diamondkdd@mail.ru
ORCID iD: 0009-0009-4895-0092
Dermatovenereologist, Head of Outpatient Department No. 4
Russian Federation, OmskOlga V. Pravdina
Omsk State Medical University
Email: diamondkdd@mail.ru
ORCID iD: 0000-0002-1804-6248
Dermatovenereologist, Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology and Cosmetology
Russian Federation, OmskYuri A. Novikov
Clinical Dermatovenereology Dispensary; Omsk State Medical University
Email: diamondkdd@mail.ru
ORCID iD: 0000-0003-0391-5372
Dermatovenereologist, Dr. Sci. (Med.), Associate Professor, Head of the Department of Dermatovenereology and Cosmetology; Chief Physician
Russian Federation, Omsk; OmskElena V. Radul
Omsk State Medical University
Email: diamondkdd@mail.ru
ORCID iD: 0000-0002-9395-9792
Dermatovenereologist, Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology and Cosmetology
Russian Federation, OmskReferences
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