Clinical blood test indicators as biomarkers of inflammation and psoriasis severity during methotrexate and genetically engineered biological agent therapy

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Abstract

Background: Search for sensitive, accessible, and objective biomarkers to assess systemic inflammatory activity in patients with psoriasis.

Objective: Comparative analysis of the Hematological parameters of clinical blood tests in patients with moderate to severe psoriasis depending on therapy (methotrexate or genetically engineered biological agents (GEBA)).

Materials and methods: A retrospective analysis of hematological parameters in 80 patients with moderate to severe psoriasis was conducted. Patients were divided into two groups depending on therapy. The first group included patients receiving methotrexate, and the second group included patients receiving genetically engineered biological agents (GEBA).

Results: In patients with moderate to severe psoriasis receiving different therapies (methotrexate or GEBA), the analysis revealed statistically significant differences in a number of hematological parameters: red blood cell (RBC), platelet (platelet), neutrophil, and basophil levels. Calculation of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio revealed elevated values for these indices in patients receiving methotrexate.

Conclusion: Monitoring hematological parameters and calculated indices of clinical blood tests (neutrophils/lymphocytes, platelets/lymphocytes) may provide accessible data for assessing the systemic inflammatory response in patients with psoriasis treated with methotrexate or GEBA.

About the authors

M. N. Vikhreva

Penza Institute for Advanced Medical Training, Branch of the Russian Medical Academy of Continuous Professional Education

Author for correspondence.
Email: vichreva.87@mail.ru
ORCID iD: 0009-0002-7977-5441

Department of Allergology and Immunology with a Course in Dermatovenereology and Cosmetology, Assistant Professor

Russian Federation, Penza

A. A. Martynov

Russian Medical Academy of Continuous Professional Education

Email: vichreva.87@mail.ru
ORCID iD: 0000-0002-5756-2747

Department of Dermatovenereology and Cosmetology

Russian Federation, Moscow

D. A. Sychev

World-Class Genomic Research Center “Center for Predictive Genetics, Pharmacogenetics, and Personalized Therapy”, Russian Scientific Center of Surgery named after Academician B.V. Petrovsky; Russian Medical Academy of Continuous Professional Education

Email: vichreva.87@mail.ru
ORCID iD: 0000-0002-4496-3680

Department of Clinical Pharmacology and Therapy named after Academician B.E. Votchal, Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences, Academician of the Russian Academy of Sciences, Head of the Department, Scientific Director 

Russian Federation, Moscow; Moscow

O. A. Levashova

Penza Institute for Advanced Medical Training, Branch of the Russian Medical Academy of Continuous Professional Education

Email: vichreva.87@mail.ru
ORCID iD: 0000-0002-8440-6598

Department of Medical Microbiology and Laboratory Medicine

Russian Federation, Penza

E. A. Orlova

Penza Institute for Advanced Medical Training, Branch of the Russian Medical Academy of Continuous Professional Education

Email: vichreva.87@mail.ru
ORCID iD: 0000-0002-3902-2018

Department of Allergology and Immunology with a Course in Dermatovenereology and Cosmetology

Russian Federation, Penza

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