The informative value of neonatal TSH in assessing iodine status in the Republic of Karelia

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Abstract

Background: Neonatal screening, including determination of thyroid-stimulating hormone (TSH) from the pituitary gland, is an effective method for the timely diagnosis of congenital primary hypothyroidism. In accordance with WHO recommendations, neonatal TSH levels can be used to assess iodine deficiency.

Objective: Assessment of the incidence of congenital hypothyroidism in the Republic of Karelia and analysis of neonatal TSH levels as an epidemiological indicator of iodine deficiency.

Materials and methods: A statistical analysis of neonatal screening results for congenital hypothyroidism in the Republic of Karelia from 2016 to 2024 was conducted.

Results: The incidence of congenital hypothyroidism in the Republic of Karelia was 1:4411 newborns, which is comparable to data for the Russian Federation. The incidence of TSH>5 mU/L in neonatal screening was less than 7%, indicating low sensitivity of this indicator for areas with mild iodine deficiency.

About the authors

Tatyana V. Varlamova

Petrozavodsk State University

Author for correspondence.
Email: varlamova@sampo.ru
ORCID iD: 0000-0001-5617-8893
Scopus Author ID: 58819203900

Cand. Sci. (Med.), Associate Professor

Russian Federation, Petrozavodsk

Vladimir V. Vapirov

Petrozavodsk State University

Email: vapirov@petrsu.ru
Scopus Author ID: 6603458306

Dr. Sci. (Chem.), Professor, Head of the Department of General Chemistry, A.P. Zilber Medical Institute

Russian Federation, Petrozavodsk

Elena B. Bashnina

North-Western State Medical University named after I.I. Mechnikov

Email: bashnina@mail.ru
ORCID iD: 0000-0002-7063-1161
Scopus Author ID: 6507189320

Dr. Sci. (Med.), Professor, Department of Endocrinology named after V.G. Baranov

Russian Federation, St. Petersburg

Ekaterina V. Tukhkanen

V.A. Baranov Republican Hospital

Email: mgk@medicine.karelia.ru
ORCID iD: 0009-0003-3976-0066

Head of the Medical and Genetic Consultation

Russian Federation, Petrozavodsk

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