Email this article Efficiency of Humic Substances in Patients with Inflammation and Pain Syndrome of the Knee Joint during Postoperative Medical Rehabilitation
- Authors: Umnikov A.S.1, Samoylov A.S.1, Velichko M.N.1, Shturmin A.V.1, Apryshko O.E.1, Krasnobay S.V.1, Grechukhin D.A.1, Shurygina A.A.1
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Affiliations:
- State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
- Issue: No 1 (2025)
- Pages: 71-77
- Section: In Order of Discussion
- URL: https://ogarev-online.ru/2070-1004/article/view/357670
- DOI: https://doi.org/10.33266/2070-1004-2025-1-71-77
- ID: 357670
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Abstract
Summary. The aim of the study is to evaluate the effectiveness of using a drug based on an extract of humic substances to reduce the inflammatory response and the severity of pain syndrome, as well as to accelerate functional recovery in patients in the postoperative period after surgery on the knee joint.
Materials and methods of the study. The study involved 60 patients divided into study group and control groups. Patients in the study group received a drug based on humic substances in addition to standard therapy. The effect of humic substance extract on the inflammatory response, severity of pain syndrome and functional recovery of the joint in the postoperative period was studied.
Research results and their analysis. The analysis of the study results showed a significant decrease in the levels of pro-inflammatory biomarkers (CRP, IL-6 and TNF-α), a decrease in swelling and pain, and an increase in the range of motion in the knee joint in patients receiving humic substances. In addition, subjective assessment showed high patient satisfaction with this treatment and a decrease in the need for additional analgesics. The anti-inflammatory and analgesic activity of humic substances allows us to recommend them as an effective means of improving postoperative recovery and improving the quality of life of patients after knee surgery.
About the authors
A. S. Umnikov
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Author for correspondence.
Email: olga_apryshko@mail.ru
Moscow
A. S. Samoylov
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: olga_apryshko@mail.ru
Moscow
M. N. Velichko
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: olga_apryshko@mail.ru
Moscow
A. V. Shturmin
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: olga_apryshko@mail.ru
Moscow
O. E. Apryshko
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: olga_apryshko@mail.ru
Researcher at the Laboratory of Big Data and Regenerative Medicine 23, Marshala Novikova str., Moscow, 123098, Russia
S. V. Krasnobay
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: olga_apryshko@mail.ru
Moscow
D. A. Grechukhin
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: olga_apryshko@mail.ru
Moscow
A. A. Shurygina
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: olga_apryshko@mail.ru
Moscow
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